Dr. Chirag Bhingradiya MBBS , Pediatrics

Yes, you can take Pyrit with tramadol. The combination of Pyrit and tramadol are prescribed by doctors to relieve from severe to moderate pain. However, do not take it on your own.

Dr. Kishan Barnwal MBBS , General Physician

Yes, Pyrit can be taken safely with a less sedative antihistaminic drug like cetirizine and loratadine etc. No harmful effects are reported. However, another group of antihistamine drug which causes drowsiness and sleepiness like chlorpheniramine, diphenhydramine etc. should not be taken together unless and until recommended by your doctor.

Dr Anjum Mujawar MBBS, MBBS , Emergency Medicine

Pyrit is a safe drug no much precautions are to be taken. However, alcohol should be completely avoided. If you have any previous history of kidney and liver diseases keep your doctor informed before taking this drug.

ravi udawat MBBS , General Physician

As we know Pyrit is most widely used 'over-the-counter' analgesic/antipyretic medicine. However, paracetamol overdose can cause serious adverse effects on the liver, it may be fatal. But fortunately, there is an antidote, N-acetylcysteine (NAC) given within 8 hours of Pyrit ingestion which usually can prevent all serious side effects of Pyrit poisoning. However, do not take NAC without consulting a doctor as your doctor will tell you the right way and methods to help you relieve from this drug poisoning.

Although it's believed that Pyrit works mainly in the central nervous system (Brain and Spine). It prevents the release of prostaglandin, which is responsible for increasing pain and body temperature. It effectively reduces the intensity of pain signals to the brain.