Divalproex Tablet - Divaa OD 250 Tablet ER

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    Divalproex Information

    Divalproex is a prescription medicine. It is typically used for the treatment of Epilepsy, Migraine. Other than this, Divalproex has some other therapeutic uses, which have been discussed ahead.

    The optimal dosage of Divalproex is largely dependent on the individual's body weight, medical history, gender and age. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. Refer to the dosage section for a detailed discussion.

    Apart from the aforementioned side effects, Divalproex can also lead to other problems, which have been listed below. Usually, these side effects of Divalproex go away soon, and do not persist beyond the duration of the treatment. However, if these continue for a longer time, consult your doctor right away.

    In addition, Divalproex's effect is Severe during pregnancy and Mild for lactating mothers. Warnings related to Divalproex's effects on the liver, heart and kidney, if any, have been listed below.

    Divalproex is contraindicated in people with pre-existing medical conditions like Depression, Liver Disease as it can result in adverse effects. The section on Divalproex contraindications lists all such conditions.

    Additionally, Divalproex may also adversely react with other medicines. See below for a complete list.

    You should also be aware that Divalproex is not safe while driving, and is not addiction.



    Divalproex Benefits & Uses

    Divalproex is used to treat the following -

    Main Benefits

    Other Benefits

    Divalproex Dosage & How to Take

    This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

    Find the right dosage based on disease and age

    Age Group Dosage
    Adult
    • Disease: Epilepsy
    • Before or After Meal: After Meal
    • Single Maximum Dose: 5 mg/kg
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 3 daily
    • Course Duration: As directed by the doctor
    • Special Instructions: Dose can be increased by 5 - 10 mg /kg/day every week until seizures are controlled.
    13 - 18 years (Adolescent)
    • Disease: Epilepsy
    • Before or After Meal: After Meal
    • Single Maximum Dose: 5 mg/kg
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 3 daily
    • Course Duration: As directed by the doctor
    • Special Instructions: Dose can be increased by 5 - 10 mg /kg/day every week until seizures are controlled
    Geriatric
    • Disease: Mania
    • Before or After Meal: After Meal
    • Single Maximum Dose: 250 mg
    • Dosage Form: Tablet
    • Dosage Route: Oral
    • Frequency: 3 daily
    • Course Duration: As directed by the doctor
    • Special Instructions: delayed-release tablet


    Divalproex Side Effects

    Based on research, the following side effects have been observed when Divalproex is used -

    Severe

    Moderate

    Mild

    Divalproex Related Warnings

    • Is the use of Divalproex safe for pregnant women?


      Divalproex should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

      Severe
    • Is the use of Divalproex safe during breastfeeding?


      Breastfeeding women can take Divalproex as it bears very minor side effects for them.

      Mild
    • What is the effect of Divalproex on the Kidneys?


      Divalproex rarely affects the kidneys.

      Mild
    • What is the effect of Divalproex on the Liver?


      Divalproex is rarely harmful for the liver.

      Mild
    • What is the effect of Divalproex on the Heart?


      Divalproex is completely safe for the heart.

      Safe


    Severe Interaction of Divalproex with Other Drugs

    Divalproex should not be taken with following medicines due to severe side effects it may cause to patients -

    Severe

    Moderate

    Mild



    Divalproex Contraindications

    If you are suffering from any of the following diseases, you should not take Divalproex unless your doctor advises you to do so -



    Frequently asked Questions about Divalproex

    • Is this Divalproex habit forming or addictive?


      Divalproex does not cause addiction.

      No
    • Is it safe to drive or operate heavy machinery when consuming?


      After taking Divalproex, you should not drive or work on any heavy machine, as Divalproex can make you drowsy.

      Dangerous
    • Is it safe?


      Yes, but consume Divalproex only on doctor's advice.

      Safe, but take only on Doctor's advise
    • Is it able to treat mental disorders?


      Yes, this Divalproex works for mental disorders.

      Yes

    Divalproex Interactions with Food and Alcohol

    • Interaction between Food and Divalproex


      You can take Divalproex with food.

      Safe
    • Interaction between Alcohol and Divalproex


      Consumption of alcohol and Divalproex together may have severe effects on your health.

      Severe


    Frequently asked Questions about Divalproex

    Question about 5 years ago

    Does Divalproex make you sleepy?

    Dr. Saikat Mukherjee MBBS , General Physician

    Yes, Divalproex may make you sleepy because it causes drowsiness, dizziness or sedation. It is a common side effect of this medicine. Do not drive vehicle or operate machinery after taking this medicine.

    Question almost 6 years ago

    How does Divalproex work?

    Dr. Manoj Meena MBBS , General Physician

    Divalproex works by relaxing the muscles of the body and suppressing abnormal activity of nerve cells in the brain through an increase in activity of a chemical messenger known as GABA (gamma-aminobutyric acid) by inhibiting the enzymes which are responsible for its decreased concentration of GABA in the brain. In this way Divalproex provides Thus, relief from the seizure and mania associated with bipolar disorder.

    Question over 5 years ago

    Can Divalproex cause constipation?

    Dr. MBBS , Dermatology, General Physician, Dietician, Infectious Disease, Sexual Medicine & Marital Therapy, Obstetrics & Gynaecology, AIDS/HIV Sexually Transmitted Infections

    Yes, Divalproex can cause constipation. It is a common side effect of this drug. However, the exact cause behind constipation is not known. If you are experiencing severe constipation after taking this drug, then please consult your doctor and follow his/her instructions.

    Question over 5 years ago

    Is Divalproex safe to use?

    Dr. Bharat MBBS , General Physician

    Yes, Divalproex is safe to use, if taken in the prescribed amount for a specified time as advised by the doctor. However, few side effects are observed at the therapeutic doses such as chest pain, dizziness, tremor, and confusion. Do not hesitate to inform your doctor if you are facing any of the above.

    Question over 5 years ago

    Can I take Divalproex with tramadol?

    Dr. Mayank Yadav MBBS , General Physician

    Yes, you can take Divalproex with tramadol only on your doctor's advice because taking these drugs together might cause increase the risk of side effects such as difficulty concentrating, drowsiness, and confusion.



    See all substitutes for Divalproex


    This medicine data has been created by -

    Vikas Chauhan

    B.Pharma, Pharmacy
    5 Years of Experience


    References

    KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 418

    US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Depakote (divalproex sodium)

    US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Depakote Er (divalproex sodium)



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