Zobisted

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Zobisted Information

Zobisted is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaZobisted is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Zobisted inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Zobisted induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Zobisted Benefits & Uses

Zobisted is used to treat the following -

Main Benefits

Other Benefits

Zobisted Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Zobisted Side Effects

Based on research, the following side effects have been observed when Zobisted is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Zobisted Related Warnings

  • Is the use of Zobisted safe for pregnant women?


    Zobisted shows severe side effect on pregnant women. For this reason, pregnant women should only take it after taking medical advice.

    Severe
  • Is the use of Zobisted safe during breastfeeding?


    Taking Zobisted may lead to serious side effects if you are breastfeeding. Zobisted should not be taken by breastfeeding women unless prescribed by the doctor.

    Severe
  • What is the effect of Zobisted on the Kidneys?


    Zobisted is completely safe for kidneys.

    Safe
  • What is the effect of Zobisted on the Liver?


    Zobisted can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate
  • What is the effect of Zobisted on the Heart?


    Zobisted can have moderate side effects on the heart. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate

Severe Interaction of Zobisted with Other Drugs

Zobisted should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Zobisted Contraindications

If you are suffering from any of the following diseases, you should not take Zobisted unless your doctor advises you to do so -


Frequently asked Questions about Zobisted

  • Is this Zobisted habit forming or addictive?


    No, you will not get addicted to Zobisted.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Zobisted can make you feel drowsy.

    Dangerous
  • Is it safe?


    Yes, but consume Zobisted only on doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, the use of Zobisted in mental disorders is not effective.

    No

Zobisted Interactions with Food and Alcohol

  • Interaction between Food and Zobisted


    When consumed with certain foods, Zobisted may take longer to have an effect. Contact your doctor about this.

    Mild
  • Interaction between Alcohol and Zobisted


    Due to lack of research, there is no information about the side effects of taking Zobisted with alcohol.

    Unknown

See all substitutes for Zobisted


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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