Bortezest 3.5mg Injection

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1 Injection in 1 Vial Out of Stock
₹ 20000
1 Injection 1 Vial ₹ 20000
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Bortezest 3.5mg Injection

1 Injection in 1 Vial
₹ 20000
1 Injection | 1 Vial
₹ 20000
people have bought this recently

Bortezest 3.5mg Injection Information

Bortezest is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaBortezest is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Bortezest inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Bortezest induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.

Side Effects

Common side effects: Fatigue, Nausea and vomiting, Peripheral neuropathy, Diarrhea or constipation, Low blood cell counts (anemia, leukopenia and thrombocytopenia)

Serious side effects: Severe neuropathy, Cardiac complications, Liver dysfunction, pulmonary issues

Precautions

  1. InfectionsBortezest may suppress the immune system, increasing the risk of infections.

  2. Liver and Kidney Function: Use cautiously in patients with impaired liver or kidney function.

  3. Pregnancy and LactationBortezest can cause harm to the fetus and should not be used during pregnancy. Breastfeeding is also not recommended during treatment.

  4. Peripheral Neuropathy: Monitor for symptoms like tingling, numbness, or pain in extremities.

Drug Interactions

  • Medications: May interact with drugs like CYP3A4 inhibitors (e.g., ketoconazole) and inducers (e.g., rifampin).

  • Herbal Products: Avoid St. John’s Wort as it may reduce Bortezest's effectiveness.

Dosage and Administration

  • FormulationBortezest is available as an injectable solution.

  • Route of Administration: It can be given intravenously (IV) or subcutaneously (SC).

  • Dosage: The typical dose is 1.3 mg/m² body surface area, administered twice weekly for two weeks, followed by a 10-day rest period. Dosage and duration may vary based on the condition being treated and patient response.

Storage and Handling

  • Store Bortezest vials at controlled room temperature.

  • Reconstituted solutions should be used promptly or stored as per manufacturer instructions.



Bortezest 3.5mg Injection Benefits & Uses

Bortezest 3.5mg Injection is used to treat the following -

Main Benefits

Other Benefits

Bortezest 3.5mg Injection Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Bortezest 3.5mg Injection Related Warnings

  • Is the use of Bortezest 3.5mg Injection safe for pregnant women?


    Bortezest should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

    Severe
  • Is the use of Bortezest 3.5mg Injection safe during breastfeeding?


    Women who are breastfeeding may experience severe harmful effects after taking Bortezest. It should only be taken after medical advice.

    Severe
  • What is the effect of Bortezest 3.5mg Injection on the Kidneys?


    Bortezest does not damage the kidneys.

    Safe
  • What is the effect of Bortezest 3.5mg Injection on the Liver?


    There may be an adverse effect on the liver after taking Bortezest. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Bortezest 3.5mg Injection on the Heart?


    The heart can be affected by Bortezest. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart the medicine only after medical advice.

    Moderate


Severe Interaction of Bortezest 3.5mg Injection with Other Drugs

Bortezest 3.5mg Injection should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Bortezest 3.5mg Injection Contraindications

If you are suffering from any of the following diseases, you should not take Bortezest 3.5mg Injection unless your doctor advises you to do so -



Frequently asked Questions about Bortezest 3.5mg Injection

  • Is this Bortezest 3.5mg Injection habit forming or addictive?


    Bortezest 3.5mg Injection is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Bortezest 3.5mg Injection can make you feel drowsy.

    Dangerous
  • Is it safe?


    Yes, Bortezest 3.5mg Injection is safe but you must consult your doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Bortezest 3.5mg Injection is unable to treat or cure mental disorders.

    No

Bortezest 3.5mg Injection Interactions with Food and Alcohol

  • Interaction between Food and Bortezest 3.5mg Injection


    When consumed with certain foods, Bortezest 3.5mg Injection may take longer to have an effect. Contact your doctor about this.

    Mild
  • Interaction between Alcohol and Bortezest 3.5mg Injection


    Information about the interaction of Bortezest 3.5mg Injection and alcohol is not currently available because this topic has not been researched yet.

    Unknown


See all substitutes for Bortezest



This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience



References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)



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