Tezomib

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Tezomib Information

Tezomib is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaTezomib is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Tezomib inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Tezomib induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Tezomib Benefits & Uses

Tezomib is used to treat the following -

Main Benefits

Other Benefits

Tezomib Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Tezomib Side Effects

Based on research, the following side effects have been observed when Tezomib is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Tezomib Related Warnings

  • Is the use of Tezomib safe for pregnant women?


    Tezomib can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Tezomib safe during breastfeeding?


    Tezomib should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.

    Severe
  • What is the effect of Tezomib on the Kidneys?


    Tezomib does not damage the kidneys.

    Safe
  • What is the effect of Tezomib on the Liver?


    Tezomib can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate
  • What is the effect of Tezomib on the Heart?


    You may experience side effects on your heart after taking Tezomib. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.

    Moderate

Severe Interaction of Tezomib with Other Drugs

Tezomib should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Tezomib Contraindications

If you are suffering from any of the following diseases, you should not take Tezomib unless your doctor advises you to do so -


Frequently asked Questions about Tezomib

  • Is this Tezomib habit forming or addictive?


    Tezomib does not cause addiction.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    You may feel sleepy or tired after taking Tezomib. So it is best to avoid driving.

    Dangerous
  • Is it safe?


    Tezomib should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, the use of Tezomib in mental disorders is not effective.

    No

Tezomib Interactions with Food and Alcohol

  • Interaction between Food and Tezomib


    Tezomib may take longer to act if you eat some foods while taking it. Follow your doctor's advice on this.

    Mild
  • Interaction between Alcohol and Tezomib


    No research has been done on this till date. Therefore, it is not known what the effect of taking Tezomib with alcohol will be.

    Unknown

See all substitutes for Tezomib


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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