Mibsar

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Mibsar Information

Mibsar is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaMibsar is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Mibsar inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Mibsar induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Mibsar Benefits & Uses

Mibsar is used to treat the following -

Main Benefits

Other Benefits

Mibsar Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Mibsar Side Effects

Based on research, the following side effects have been observed when Mibsar is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Mibsar Related Warnings

  • Is the use of Mibsar safe for pregnant women?


    Mibsar should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

    Severe
  • Is the use of Mibsar safe during breastfeeding?


    Mibsar should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.

    Severe
  • What is the effect of Mibsar on the Kidneys?


    Using Mibsar does not have any harmful effects on kidneys.

    Safe
  • What is the effect of Mibsar on the Liver?


    There may be an adverse effect on the liver after taking Mibsar. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Mibsar on the Heart?


    There may be an adverse effect on the heart after taking Mibsar. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.

    Moderate

Severe Interaction of Mibsar with Other Drugs

Mibsar should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Mibsar Contraindications

If you are suffering from any of the following diseases, you should not take Mibsar unless your doctor advises you to do so -


Frequently asked Questions about Mibsar

  • Is this Mibsar habit forming or addictive?


    Mibsar is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Mibsar can make you feel drowsy.

    Dangerous
  • Is it safe?


    Mibsar should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Mibsar cannot treat any kind of mental disorder.

    No

Mibsar Interactions with Food and Alcohol

  • Interaction between Food and Mibsar


    When consumed with certain foods, Mibsar may take longer to have an effect. Contact your doctor about this.

    Mild
  • Interaction between Alcohol and Mibsar


    Due to lack of research, there is no information about the side effects of taking Mibsar with alcohol.

    Unknown

See all substitutes for Mibsar


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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