Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Metafolate treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metafolate induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Vipin Khadse MBBS , General Physician

Metafolate is not a known cause of alopecia (hair loss). However, the conditions treated by Metafolate type 2 diabetes and PCOS, often list hair loss as a possible symptom.

Dr. Sameer Awadhiya MBBS , Pediatrics

Yes, you can take Metafolate with a beta-blocker. People with diabetes tend to develop heart disease or stroke at an earlier age than the general population. One reason for this is that high glucose levels increase your risk of high blood pressure (hypertension). No harmful interactions are seen between them. However, a recent study suggests that beta-blockers can decrease the plasma level of Metafolate and long-term use can increase lactic acid and uric acid in the blood.

Dr. Vedprakash Verma MBBS, MD , Cardiology

Yes, Metafolate is safe to use, many people have side effects at first, they usually diminish and then go away completely in a few weeks. A few people find they cannot tolerate metformin, there are other drugs but metformin is usually the first choice. It is very safe

Dr. Joydeep Sarkar MBBS , Internal Medicine

Yes, Metafolate can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Metafolate causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Metafolate may need to be adjusted.