Capitab by BDR Pharmaceuticals contains Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), used in the treatment of various cancers. Capecitabine is designed to selectively activate in tumor tissues, reducing systemic side effects and enhancing therapeutic efficacy.
Composition:
Active Ingredient: Capecitabine 500 mg.
Form: Film-coated tablet.
Route of Administration: Oral.
Indications:
Colorectal Cancer:
Treatment for metastatic colorectal cancer.
Adjuvant therapy for patients with Dukes' C colon cancer after surgery.
Breast Cancer:
Treatment of locally advanced or metastatic breast cancer.
Commonly used in combination with docetaxel after anthracycline-based chemotherapy failure.
Gastric Cancer:
Used in advanced gastric cancer, often in combination with platinum-based regimens.
Off-Label Uses:
Sometimes prescribed for other solid tumors under clinical discretion.
Mechanism of Action:
Capecitabine is converted enzymatically into 5-fluorouracil (5-FU) within tumor cells. The active metabolite interferes with DNA synthesis by:
Inhibiting thymidylate synthase, which blocks thymidine production needed for DNA replication.
Disrupting RNA and protein synthesis, ultimately leading to cancer cell death.
This tumor-selective activation minimizes systemic toxicity.
Capitab is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult |
|
| Geriatric |
|
| Adult(Female) |
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Based on research, the following side effects have been observed when Capitab is used -
Moderate
Mild
Is the use of Capitab safe for pregnant women?
Capitab can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.
Is the use of Capitab safe during breastfeeding?
Capitab may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.
What is the effect of Capitab on the Kidneys?
Kidney can be affected by Capitab. If you experience any unwanted effects of this drug, stop taking it. You should take it again only after medical advice.
What is the effect of Capitab on the Liver?
Capitab can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.
What is the effect of Capitab on the Heart?
Very few cases of side effects of Capitab on the heart have been reported.
Capitab should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Capitab unless your doctor advises you to do so -
Is this Capitab habit forming or addictive?
Capitab is not addictive in nature.
Is it safe to drive or operate heavy machinery when consuming?
After taking Capitab, you should not drive or work on any heavy machine, as Capitab can make you drowsy.
Is it safe?
Yes, Capitab is safe but you must consult your doctor before taking it.
Is it able to treat mental disorders?
Capitab is unable to treat or cure mental disorders.
Interaction between Food and Capitab
Taking Capitab with food is safe.
Interaction between Alcohol and Capitab
It is difficult to say anything about the effect of Capitab and alcohol. No research has been done on this yet.
This medicine data has been created by -
References
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 272-273
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 864
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Xeloda® (capecitabine)
Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Capecitabine Sandoz® (capecitabine)