Bortiad

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Bortiad Information

Bortiad is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaBortiad is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Bortiad inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Bortiad induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Bortiad Benefits & Uses

Bortiad is used to treat the following -

Main Benefits

Other Benefits

Bortiad Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Bortiad Side Effects

Based on research, the following side effects have been observed when Bortiad is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Bortiad Related Warnings

  • Is the use of Bortiad safe for pregnant women?


    Bortiad can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

    Severe
  • Is the use of Bortiad safe during breastfeeding?


    Bortiad may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

    Severe
  • What is the effect of Bortiad on the Kidneys?


    Bortiad is not harmful for kidneys.

    Safe
  • What is the effect of Bortiad on the Liver?


    There may be an adverse effect on the liver after taking Bortiad. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Bortiad on the Heart?


    Bortiad may cause harmful effects on the heart. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate

Severe Interaction of Bortiad with Other Drugs

Bortiad should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Bortiad Contraindications

If you are suffering from any of the following diseases, you should not take Bortiad unless your doctor advises you to do so -


Frequently asked Questions about Bortiad

  • Is this Bortiad habit forming or addictive?


    Bortiad is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Bortiad as you may feel sleepy.

    Dangerous
  • Is it safe?


    Bortiad should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    There is no benefit of taking Bortiad for mental disorders.

    No

Bortiad Interactions with Food and Alcohol

  • Interaction between Food and Bortiad


    Bortiad may take longer to act if you eat some foods while taking it. Follow your doctor's advice on this.

    Mild
  • Interaction between Alcohol and Bortiad


    No research has been done on this till date. Therefore, it is not known what the effect of taking Bortiad with alcohol will be.

    Unknown

See all substitutes for Bortiad


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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