Bortezest

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Bortezest 2mg Injection 1 इंजेक्शन 1 शीशी ₹ 5891
Bortezest 3.5mg Injection 1 इंजेक्शन 1 शीशी ₹ 20000

Bortezest Information

Bortezest is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaBortezest is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Bortezest inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Bortezest induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Bortezest Benefits & Uses

Bortezest is used to treat the following -

Main Benefits

Other Benefits

Bortezest Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Bortezest Side Effects

Based on research, the following side effects have been observed when Bortezest is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Bortezest Related Warnings

  • Is the use of Bortezest safe for pregnant women?


    Bortezest should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.

    Severe
  • Is the use of Bortezest safe during breastfeeding?


    Women who are breastfeeding may experience severe harmful effects after taking Bortezest. It should only be taken after medical advice.

    Severe
  • What is the effect of Bortezest on the Kidneys?


    Bortezest does not damage the kidneys.

    Safe
  • What is the effect of Bortezest on the Liver?


    There may be an adverse effect on the liver after taking Bortezest. If you observe any side effects on your body then stop taking this drug. Take this medicine again only if your doctor advises you to do so.

    Moderate
  • What is the effect of Bortezest on the Heart?


    The heart can be affected by Bortezest. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart the medicine only after medical advice.

    Moderate

Severe Interaction of Bortezest with Other Drugs

Bortezest should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Bortezest Contraindications

If you are suffering from any of the following diseases, you should not take Bortezest unless your doctor advises you to do so -


Frequently asked Questions about Bortezest

  • Is this Bortezest habit forming or addictive?


    Bortezest is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Bortezest can make you feel drowsy.

    Dangerous
  • Is it safe?


    Yes, Bortezest is safe but you must consult your doctor before taking it.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    Bortezest is unable to treat or cure mental disorders.

    No

Bortezest Interactions with Food and Alcohol

  • Interaction between Food and Bortezest


    When consumed with certain foods, Bortezest may take longer to have an effect. Contact your doctor about this.

    Mild
  • Interaction between Alcohol and Bortezest


    Information about the interaction of Bortezest and alcohol is not currently available because this topic has not been researched yet.

    Unknown

See all substitutes for Bortezest


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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