Borteshil

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Borteshil Information

Borteshil is an antineoplastic (anti-cancer) medication that belongs to the class of proteasome inhibitors. It is primarily used for the treatment of multiple myeloma and mantle cell lymphoma. By disrupting cellular processes, it helps to prevent cancer cells from growing and multiplying.

Uses

Multiple MyelomaBorteshil is often used as a first-line treatment in combination with other drugs such as dexamethasone or lenalidomide.

Mantle Cell Lymphoma (MCL): It is approved for the treatment of MCL in patients who have received at least one prior therapy.

Borteshil inhibits the 26S proteasome, a protein complex involved in breaking down unneeded or damaged proteins. By inhibiting the proteasome, Borteshil induces apoptosis (programmed cell death) in cancer cells, disrupting their survival mechanisms.


Borteshil Benefits & Uses

Borteshil is used to treat the following -

Main Benefits

Other Benefits

Borteshil Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor
Geriatric
  • Disease: Multiple Myeloma
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 2 mg
  • Dosage Route: Parenteral
  • Frequency: 2 Weekly
  • Course Duration: 2 weeks
  • Special Instructions: As prescribed by the doctor

Borteshil Side Effects

Based on research, the following side effects have been observed when Borteshil is used -

Severe

Moderate

  • Bone Pain
  • Orthostatic Hypotension (Sudden Lowering of Blood Pressure on Standing)

Mild

Borteshil Related Warnings

  • Is the use of Borteshil safe for pregnant women?


    Borteshil has many dangerous side effects in pregnant women. If you are pregnant, do not consume Borteshil without medical advice.

    Severe
  • Is the use of Borteshil safe during breastfeeding?


    Borteshil may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.

    Severe
  • What is the effect of Borteshil on the Kidneys?


    Borteshil does not damage the kidneys.

    Safe
  • What is the effect of Borteshil on the Liver?


    Borteshil may cause harmful effects on liver. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate
  • What is the effect of Borteshil on the Heart?


    There may be an adverse effect on the heart after taking Borteshil. If you observe any side effects on your body then stop taking this drug. Restart this medicine only if your doctor advises you to do so.

    Moderate

Severe Interaction of Borteshil with Other Drugs

Borteshil should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate


Borteshil Contraindications

If you are suffering from any of the following diseases, you should not take Borteshil unless your doctor advises you to do so -


Frequently asked Questions about Borteshil

  • Is this Borteshil habit forming or addictive?


    Borteshil does not cause addiction.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should not drive or operate heavy machinery after taking Borteshil as you may feel sleepy.

    Dangerous
  • Is it safe?


    Yes, but take Borteshil only as per medical advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    There is no benefit of taking Borteshil for mental disorders.

    No

Borteshil Interactions with Food and Alcohol

  • Interaction between Food and Borteshil


    Borteshil may take longer to act if you eat some foods while taking it. Follow your doctor's advice on this.

    Mild
  • Interaction between Alcohol and Borteshil


    Information about the interaction of Borteshil and alcohol is not currently available because this topic has not been researched yet.

    Unknown

See all substitutes for Borteshil


This medicine data has been created by -

Vikas Chauhan
B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 234-235

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 871

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Velcade® (bortezomib)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Bortezomib Aft (Bortezomib)


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