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Janumet 500 Tablet, a prescription drug, is manufactured in various forms such as Tablet. Primarily, it is used for the treatment of Diabetes. Other than this, Janumet 500 Tablet has some other therapeutic uses, which have been discussed ahead.
The correct dosage of Janumet 500 Tablet depends on the patient's age, gender, and medical history. The condition it has been prescribed for, and the route of administration also determine the right dosage. For detailed information on this, read through the dosage section.
Common side effects of Janumet 500 Tablet include Nausea or vomiting, Headache, Diarrhoea. Some other side effects of Janumet 500 Tablet have been listed ahead. Usually, these side effects of Janumet 500 Tablet go away soon, and do not persist beyond the duration of the treatment. However, if these continue for a longer time, consult your doctor right away.
It is also important to note that Janumet 500 Tablet has a Mild effect for pregnant women and Safe effect on lactating mothers. It is important to know if Janumet 500 Tablet has any effect on the kidney, liver and heart. Information on such adverse effects, if any, has been given in the Janumet 500 Tablet related warnings section.
Janumet 500 Tablet is not recommended if you suffer from certain medical conditions as it can have adverse effects. Pancreatitis are examples of such conditions. Other contraindications of Janumet 500 Tablet have been discussed in the sections ahead.
Drug interactions for Janumet 500 Tablet have been reported in the medical literature. See below for a complete list.
In addition to these precautions, you may also note that Janumet 500 Tablet is not safe while driving, and is is not addictive in nature.
Janumet 500 Tablet is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
Age Group | Dosage |
Adult |
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Geriatric |
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Is the use of Janumet 500 Tablet safe for pregnant women?
Janumet has mild to no side effects in pregnant women.
Is the use of Janumet 500 Tablet safe during breastfeeding?
Janumet is completely safe for breastfeeding women.
What is the effect of Janumet 500 Tablet on the Kidneys?
Janumet may cause harmful effects on kidney. if you feel its having any such effect, then stop taking this drug, and restart only on your doctor's advice.
What is the effect of Janumet 500 Tablet on the Liver?
Using Janumet does not have any harmful effects on the liver.
What is the effect of Janumet 500 Tablet on the Heart?
Information about safety of Janumet for heart is not available since scientific research on this is yet to be done.
If you are suffering from any of the following diseases, you should not take Janumet 500 Tablet unless your doctor advises you to do so -
Is this Janumet 500 Tablet habit forming or addictive?
No, there is no any evidence that Janumet 500 Tablet is addictive.
Is it safe to drive or operate heavy machinery when consuming?
After taking Janumet 500 Tablet you may feel sleepy. So it is not advised to perform these activities.
Is it safe?
Janumet 500 Tablet is safe but it is important to consult a doctor before taking it.
Is it able to treat mental disorders?
No, the use of Janumet 500 Tablet in mental disorders is not effective.
Interaction between Food and Janumet 500 Tablet
Due to the absence of research, it is difficult to say how Janumet 500 Tablet and food will interact.
Interaction between Alcohol and Janumet 500 Tablet
No research has been done on this till date. Therefore, it is not known what the effect of taking Janumet 500 Tablet with alcohol will be.
Janumet works by decreasing the hepatic glucose production. It also works to lower blood sugar by increasing your sensitivity to insulin and decreasing the amount of glucose that is absorbed from the food you eat.
Yes, Janumet can cause some sleep problems, especially insomnia. On the other hand, Janumet has proven to be useful for preventing sleep apnea. The exact relationship between Janumet and sleep problems is still not clear, and further studies are needed for a clearer understanding.
Janumet can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime.
Lactic acidosis associated with Janumet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Janumet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst.
Yes, Janumet can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.
This medicine data has been created by -
B.Pharma, Pharmacy
5 Years of Experience
References
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Glucophage® (metformin hydrochloride)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 275-276
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 825-826
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Januvia® (sitagliptin)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 274-275
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1143-1144
EPAR summary for the public [Internet]: Janumet sitagliptin / metformin hydrochloride. EMA/370017/2013 EMEA/H/C/000861