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Janumet is a prescription drug, available for use as Tablet,Capsule. Primarily, it is used for the treatment of Diabetes. The alternative uses of Janumet have also been explained below.
The correct dosage of Janumet depends on the patient's age, gender, and medical history. Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage. This information has been provided in detail in the dosage section.
Common side effects of Janumet include Nausea or vomiting, Headache, Diarrhoea. Apart from the aforementioned side effects, Janumet can also lead to other problems, which have been listed below. Normally, these side effects of Janumet are not long lasting and go away when the treatment is finished. Please speak with your doctor if these side effects worsen or persist for a longer duration.
Janumet's effect during pregnancy is Mild and Safe while nursing. In addition, Janumet's effects on the liver, heart and kidney are discussed below in the Janumet related warnings section.
Janumet can cause adverse effects in certain medical conditions. It is strongly recommended to avoid Janumet in conditions like Pancreatitis. Other contraindications of Janumet have been discussed in the sections ahead.
Drug reaction of Janumet with other medicines has been reported. A complete list of these interactions is given below.
Along with the above-mentioned precautions, remember that taking Janumet is considered not safe while driving, and is not addictive.
Janumet is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
Age Group | Dosage |
Adult |
|
Geriatric |
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Is the use of Janumet safe for pregnant women?
Janumet has mild to no side effects in pregnant women.
Is the use of Janumet safe during breastfeeding?
Janumet is completely safe for breastfeeding women.
What is the effect of Janumet on the Kidneys?
Janumet may cause harmful effects on kidney. if you feel its having any such effect, then stop taking this drug, and restart only on your doctor's advice.
What is the effect of Janumet on the Liver?
Using Janumet does not have any harmful effects on the liver.
What is the effect of Janumet on the Heart?
Information about safety of Janumet for heart is not available since scientific research on this is yet to be done.
Janumet should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Janumet unless your doctor advises you to do so -
Is this Janumet habit forming or addictive?
No, there is no any evidence that Janumet is addictive.
Is it safe to drive or operate heavy machinery when consuming?
After taking Janumet you may feel sleepy. So it is not advised to perform these activities.
Is it safe?
Janumet is safe but it is important to consult a doctor before taking it.
Is it able to treat mental disorders?
No, the use of Janumet in mental disorders is not effective.
Interaction between Food and Janumet
Due to the absence of research, it is difficult to say how Janumet and food will interact.
Interaction between Alcohol and Janumet
No research has been done on this till date. Therefore, it is not known what the effect of taking Janumet with alcohol will be.
Janumet works by decreasing the hepatic glucose production. It also works to lower blood sugar by increasing your sensitivity to insulin and decreasing the amount of glucose that is absorbed from the food you eat.
Yes, Janumet can cause some sleep problems, especially insomnia. On the other hand, Janumet has proven to be useful for preventing sleep apnea. The exact relationship between Janumet and sleep problems is still not clear, and further studies are needed for a clearer understanding.
Janumet can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime.
Lactic acidosis associated with Janumet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Janumet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst.
Yes, Janumet can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.
This medicine data has been created by -
B.Pharma, Pharmacy
5 Years of Experience
References
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Glucophage® (metformin hydrochloride)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 275-276
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 825-826
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Januvia® (sitagliptin)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 274-275
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1143-1144
EPAR summary for the public [Internet]: Janumet sitagliptin / metformin hydrochloride. EMA/370017/2013 EMEA/H/C/000861