Folic Acid + Methotrexate

Some of the natural sources of Folate are green leafy vegetables, fruits, nuts, meat, eggs, yeast, liver, dairy products, beans, peas, seafood, yeast, grains, beef liver, and beef kidney. Many food items are fortified with Folic acid. Folic acid is required for the synthesis of genetic material and red blood cells. Its deficiency can cause megaloblastic anemia. It is also essential for pregnant women before and during the pregnancy. Deficiency of Folic acid during pregnancy can result in premature delivery and babies with the neural tube defects.

Long-term oral use of Folic acid can be unsafe as it can cause stomach upset, gas, abdominal cramps, and diarrhea.

In rare instances, severe allergic reaction to Folic Acid + Methotrexate has been reported such as hives, breathlessness, and difficulty in swallowing.

Folic Acid + Methotrexate should be taken at the same time, whether morning or night. It should be taken with a glass of water, with or without food. 

Folic Acid + Methotrexate should not be discontinued on your own. Your doctor may want to check your recent levels of folic acid with the help of blood tests. If the reports are satisfactory then your doctor will ask you to discontinue Folic Acid + Methotrexate.