Busfan is an alkylating agent used as part of preparative regimens before hematopoietic stem cell transplantation (HSCT). It is primarily indicated for the treatment of chronic myeloid leukemia (CML) and other hematological malignancies. By suppressing bone marrow activity, Busfan creates an optimal environment for successful stem cell engraftment. Busfan injection plays a crucial role in conditioning regimens for stem cell transplantation, offering a foundation for successful treatment in hematological malignancies. While effective, its use requires careful monitoring and supportive care to manage side effects and maximize therapeutic outcomes.
Busfan exerts its effects by cross-linking DNA strands, leading to the inhibition of DNA replication and RNA transcription. This results in the destruction of rapidly dividing cells, including hematopoietic stem cells in the bone marrow, facilitating the engraftment of transplanted stem cells.
Busfan is used to treat the following -
Main Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult |
|
| Geriatric |
|
Based on research, the following side effects have been observed when Busfan is used -
Moderate
Mild
Is the use of Busfan safe for pregnant women?
Busfan has many dangerous side effects in pregnant women. If you are pregnant, do not consume Busfan without medical advice.
Is the use of Busfan safe during breastfeeding?
Women who are breastfeeding, may experience serious side effects after taking Busfan. So it is adviced to consult the doctor before using it.
What is the effect of Busfan on the Kidneys?
Busfan does not damage the kidneys.
What is the effect of Busfan on the Liver?
Very few cases of side effects of Busfan on the liver have been reported.
What is the effect of Busfan on the Heart?
Side effects of Busfan rarely affect the heart.
Busfan should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Busfan unless your doctor advises you to do so -
Is this Busfan habit forming or addictive?
No, you will not get addicted to Busfan.
Is it safe to drive or operate heavy machinery when consuming?
After taking Busfan, you should not drive or work on any heavy machine, as Busfan can make you drowsy.
Is it safe?
Yes, Busfan is safe but you must consult your doctor before taking it.
Is it able to treat mental disorders?
No, Busfan is not used to treat mental disorders.
Interaction between Food and Busfan
Taking Busfan with food is safe.
Interaction between Alcohol and Busfan
No research has been done on this till date. Therefore, it is not known what the effect of taking Busfan with alcohol will be.
This medicine data has been created by -
References
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 258-260
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 861
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Busulfex (busulfan)
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Myleran® (busulfan)