Bufatas is an alkylating agent used as part of preparative regimens before hematopoietic stem cell transplantation (HSCT). It is primarily indicated for the treatment of chronic myeloid leukemia (CML) and other hematological malignancies. By suppressing bone marrow activity, Bufatas creates an optimal environment for successful stem cell engraftment. Bufatas injection plays a crucial role in conditioning regimens for stem cell transplantation, offering a foundation for successful treatment in hematological malignancies. While effective, its use requires careful monitoring and supportive care to manage side effects and maximize therapeutic outcomes.
Bufatas exerts its effects by cross-linking DNA strands, leading to the inhibition of DNA replication and RNA transcription. This results in the destruction of rapidly dividing cells, including hematopoietic stem cells in the bone marrow, facilitating the engraftment of transplanted stem cells.
Bufatas is used to treat the following -
Main Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult |
|
| Geriatric |
|
Based on research, the following side effects have been observed when Bufatas is used -
Moderate
Mild
Is the use of Bufatas safe for pregnant women?
Bufatas has many dangerous side effects in pregnant women. If you are pregnant, do not consume Bufatas without medical advice.
Is the use of Bufatas safe during breastfeeding?
Women who are breastfeeding, may experience serious side effects after taking Bufatas. So it is adviced to consult the doctor before using it.
What is the effect of Bufatas on the Kidneys?
There are no side effects of Bufatas on the kidneys.
What is the effect of Bufatas on the Liver?
Side effects of Bufatas rarely affect the liver.
What is the effect of Bufatas on the Heart?
Bufatas has very mild side effects on the heart.
Bufatas should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Bufatas unless your doctor advises you to do so -
Is this Bufatas habit forming or addictive?
Bufatas does not cause addiction.
Is it safe to drive or operate heavy machinery when consuming?
No, you should not drive or operate heavy machinery after taking Bufatas as you may feel sleepy.
Is it safe?
Yes, but consume Bufatas only on doctor's advice.
Is it able to treat mental disorders?
No, the use of Bufatas in mental disorders is not effective.
Interaction between Food and Bufatas
Taking Bufatas with food does not cause any problems.
Interaction between Alcohol and Bufatas
Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Bufatas.
This medicine data has been created by -
References
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 258-260
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 861
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Busulfex (busulfan)
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Myleran® (busulfan)