Dr. MBBS , Dermatology, General Physician, Dietician, Infectious Disease, Sexual Medicine & Marital Therapy, Obstetrics & Gynaecology, AIDS/HIV Sexually Transmitted Infections

No, it is recommended that you do not take Promethazine with amitriptyline which is an antidepressant with anticholinergic effects. Since Promethazine also has anticholinergic effects, both the drugs produce additive effects such as dry mouth, constipation, blurred vision, etc. 

Dr. Chinmaya Bal MBBS , General Physician

Promethazine is available in the form of injectable, tablets and syrups to be taken orally, as a suppository to be taken rectally. When taken for treating allergies, it is taken 1 to 4 times a day usually before meals or at bedtime. When used for treating cold, it is taken every 4 to 6 hours. When used for treating motion sickness, it is taken 30 to 60 minutes before travel and again after 8 to 10 hours if required. Promethazine might also be taken at bedtime before surgery to feel relaxed and sleep properly. The suppositories are meant for rectal use. Do not use them in any other body cavity. If using Promethazine liquid, avoid using a household spoon and use the measuring cup that is dispensed with the syrup. The Promethazine should be taken exactly as prescribed by your doctor.

Dr. MBBS , Dermatology, General Physician, Dietician, Infectious Disease, Sexual Medicine & Marital Therapy, Obstetrics & Gynaecology, AIDS/HIV Sexually Transmitted Infections

Yes, antipsychotics like Promethazine exert anticholinergic effects and as a result, dry mouth is one of the adverse reactions. Some of the additional anticholinergic effects are constipation, urinary retention, and blurred vision. If any of these effects present, it is important that you talk to your doctor immediately.

Dr. Gaurav MBBS , General Physician

Most antipsychotics cause weight gain and Promethazine is also one of the drugs that cause the same. Promethazine induces sleep and causes lethargy in patients due to which the physical activity gets reduced, leading to weight gain. Since weight loss is difficult for most people, emphasis should be paid on preventing weight gain using lifestyle modifications comprising a change of diet and the addition of physical activity in routine. 

Dr. Bharat MBBS , General Physician

Yes, Promethazine can be safely taken with Zantac, which is used for managing acidity and prevent ulcers in stomach and intestine.