Dr. Chinmaya Bal MBBS , General Physician

Yes Femara can be taken along with tamoxifen at the same time because tamoxifen decreases levels of letrozole by unknown mechanism. Hence taking Femara with tamoxifen at the same time should be avoided.

Dr. Faisal Mukhtar MBBS, PG Dip, DNB , Ophthalmology

Rarely, Femara causes weight fluctuation (weight gain or weight loss). However, the exact cause behind weight fluctuation is unknown but it is presumed that this occurs due to fluctuation in hormone levels in the body caused by this drug. If you experience any unusual sudden weight gain or loss after taking this drug, then consult it with your doctor without further delay.

Dr. Madhur Anand MBBS, MS , General Surgery

Femara contains letrozole that works in breast cancer by blocking an enzyme (aromatase) which prevents the conversion of androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) due to this levels of estrogen hormones drop in the body. The decrease in hormone levels leads to a reduction in tumor mass or delays the progression of tumor growth in some women. For an ovulation (infertility), it is presumed that Femara works by increasing the sensitivity of ovary to follicular stimulating hormone (FSH) and also low level of estrogen hormones in the blood is detected by the brain which in turn increases the production of a follicular stimulating hormone (FSH) which causes induction of ovulation.

Dr. Bharat MBBS , General Physician

No, Femara does not cause ovarian cysts. It has not been reported by the patients who are taking this drug. However, the possibility of ovarian cysts formation by this drug because of long-term use in high doses cannot be denied.

Dr. Madhur Anand MBBS, MS , General Surgery

Yes, Femara may cause spotting or vaginal bleeding which is harmless. It is a very rare side effect of this drug. It might occur due to fluctuation in hormone levels in the body.