Dacazee, containing Dacarbazine, is a chemotherapy agent used in the treatment of various cancers, including malignant melanoma and Hodgkin's lymphoma. It is classified as an alkylating agent that interferes with the growth of cancer cells by damaging their DNA.

Uses

• Malignant melanoma
• Hodgkin's lymphoma (in combination therapy)
• Soft tissue sarcomas (as off-label use in some cases)

Dacarbazine is metabolized in the liver to its active form, which functions as an alkylating agent. It attaches to the DNA strands in cancer cells, causing breaks and disrupting replication, ultimately leading to cell death.

Side Effects
Common side effects:

• Nausea and vomiting
• Fatigue
• Loss of appetite
• Hair loss (alopecia)
• Skin reactions

Severe side effects:

• Myelosuppression (low blood cell counts)
• Liver toxicity
• Severe allergic reactions

Precautions

• Monitor liver and kidney function regularly.
• Perform complete blood counts frequently to detect myelosuppression.
• Avoid in pregnancy and breastfeeding as it may harm the fetus or infant.
• Administer under strict medical supervision in a healthcare facility.

Dosage and Administration

Formulation: Injectable (intravenous use)

Dosage Guidelines:

• For melanoma: 2-4.5 mg/kg/day IV for 10 days, repeated every 4 weeks, or 250 mg/m²/day IV for 5 days every 3 weeks.

• For Hodgkin's lymphoma: 150 mg/m²/day IV for 5 days every 4 weeks, or a single dose of 375 mg/m² every 15 days (in combination therapy).

Storage
Store at 2-8°C (refrigerated). Protect from light and do not freeze.