Caxfila OS contains Megestrol acetate, a synthetic progestational agent primarily used in the treatment of certain cancers and as an appetite stimulant. It plays a significant role in managing weight loss and cachexia in patients with AIDS or cancer.

Uses

• Treatment of advanced breast cancer

• Treatment of advanced endometrial cancer

• Management of anorexia, cachexia, or significant weight loss in patients with AIDS or cancer

Mechanism of Action

Megestrol acetate works by inhibiting the release of gonadotropins from the pituitary gland, resulting in decreased estrogen production, which is beneficial in hormone-sensitive cancers. Additionally, it has appetite-stimulating properties.

Dosage and Administration

Breast Cancer and Endometrial Cancer:

• Recommended dose: 40 to 320 mg/day orally, divided into several doses.

Anorexia, Cachexia, or Weight Loss:

• Recommended dose: 400 to 800 mg/day orally.

• Administration: Take Caxfila OS with or without food as directed by a healthcare provider.

Missed Dose: Take the missed dose as soon as you remember unless it is close to the next scheduled dose.

Overdose: In case of overdose, seek immediate medical attention.

Side Effects

Common side effects:

• Weight gain

• Increased appetite

• Nausea

• Weakness

• Hypertension

• Mood changes

Serious side effects:

• Thrombophlebitis

• Pulmonary embolism

• Adrenal insufficiency

Precautions

• Monitor for signs of thromboembolic disorders.

• Regularly check blood sugar levels in diabetic patients.

• Use cautiously in patients with a history of deep vein thrombosis or pulmonary embolism.

Contraindications

• Pregnancy: Benzace is contraindicated in pregnancy due to potential harm to the fetus.

• Known hypersensitivity to megestrol acetate or any of its components.

Drug Interactions

• Rifampin and other enzyme inducers may reduce the effectiveness of Benzace.

• Insulin or oral hypoglycemic agents may require dosage adjustments.

Storage

• Store at room temperature between 15°C to 30°C.

• Keep out of reach of children.