Topotecan Benefits & Uses

Topotecan is used to treat the following -

Other Benefits

Ovarian Cancer

Topotecan Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult(Female)	Disease: Ovarian Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 2.5 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: 3 weeks Special Instructions: Given for 5 consecutive days, starting on day 1 of a 21 day course, 1.5 mg/ m(2)
Adult	Disease: Small Cell Lung Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 2.5 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: 3 weeks Special Instructions: Given for 5 consecutive days, starting on day 1 of a 21 day course, 1.5 mg/ m(2)
Geriatric	Disease: Small Cell Lung Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 2.5 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: 3 weeks Special Instructions: Given for 5 consecutive days, starting on day 1 of a 21 day course, 1.5 mg/ m(2)

Topotecan Side Effects

Based on research, the following side effects have been observed when Topotecan is used -

Severe

Decreased white blood cell count (neutrophils)
Anemia (Read More - Home Remedies for Anaemia)

Common

Fatigue
Nausea or vomiting
Headache
Fever (Read More - Home remedies for fever)
Weakness
Diarrhoea
Loss of appetite
पेट दर्द
Constipation (Read More - Home remedies for constipation)
Back Pain
Chills
Weight Loss

Topotecan Related Warnings

Is the use of Topotecan safe for pregnant women?

Topotecan has many dangerous side effects in pregnant women. If you are pregnant, do not consume Topotecan without medical advice.

Severe
Is the use of Topotecan safe during breastfeeding?

Topotecan should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.

Severe
What is the effect of Topotecan on the Kidneys?

Topotecan rarely affects the kidneys.

Mild
What is the effect of Topotecan on the Liver?

There are no any side effects of Topotecan on the liver.

Safe
What is the effect of Topotecan on the Heart?

There are no any side effects of Topotecan for the heart.

Safe

Severe Interaction of Topotecan with Other Drugs

Topotecan should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Clozapine

Adalimumab

Amiodarone

Amoxicillin,Omeprazole,Clarithromycin

Cabozantinib

Topotecan Contraindications

If you are suffering from any of the following diseases, you should not take Topotecan unless your doctor advises you to do so -

Anemia
Herpes
Lung Cancer
Infertility

Frequently asked Questions about Topotecan

Is this Topotecan habit forming or addictive?

No, there is no any evidence that Topotecan is addictive.

No
Is it safe to drive or operate heavy machinery when consuming?

No, you should not drive or operate heavy machinery after taking Topotecan as you may feel sleepy.

Dangerous
Is it safe?

Yes, but consume Topotecan only on doctor's advice.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

Topotecan is unable to treat or cure mental disorders.

No

Topotecan Interactions with Food and Alcohol

Interaction between Food and Topotecan

You can take Topotecan with food.

Safe
Interaction between Alcohol and Topotecan

Information about the interaction of Topotecan and alcohol is not currently available because this topic has not been researched yet.

Unknown

See all substitutes for Topotecan

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Topotecan

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1221-1223

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 866

Topotecan Injection