Pralidoxime Benefits & Uses

Pralidoxime is used to treat the following -

Other Benefits

Organophosphate Poisoning

Pralidoxime Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult	Disease: Organophosphate Poisoning Before or After Meal: As advised by a physician Single Maximum Dose: 2 g Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Geriatric	Disease: Organophosphate Poisoning Before or After Meal: As advised by a physician Single Maximum Dose: 2 g Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
13 - 18 years (Adolescent)	Disease: Organophosphate Poisoning Before or After Meal: As advised by a physician Single Maximum Dose: 50 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
2 - 12 years (Child)	Disease: Organophosphate Poisoning Before or After Meal: As advised by a physician Single Maximum Dose: 50 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Infant (1 month to 2 years)	Disease: Organophosphate Poisoning Before or After Meal: As advised by a physician Single Maximum Dose: 50 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor

Pralidoxime Side Effects

Based on research, the following side effects have been observed when Pralidoxime is used -

Moderate

Double Vision
Blurred vision
Tachycardia

Mild

Nausea or vomiting
Muscle twitching (painless)
Drowsiness
Headache
Dizziness
Hyperventilating (rapid/deep breathing)
Weak Muscles
Injection site pain

Pralidoxime Related Warnings

Is the use of Pralidoxime safe for pregnant women?

Pralidoxime can have harmful effects in pregnant women. If you experience any discomfort after using Pralidoxime, then discontinue the use and take your doctor's advice.

Moderate
Is the use of Pralidoxime safe during breastfeeding?

Breastfeeding women can take Pralidoxime as it bears very minor side effects for them.

Mild
What is the effect of Pralidoxime on the Kidneys?

Pralidoxime rarely affects the kidneys.

Mild
What is the effect of Pralidoxime on the Liver?

Pralidoxime is not harmful for the liver.

Safe
What is the effect of Pralidoxime on the Heart?

Using Pralidoxime does not have any harmful effects on the heart.

Safe

Severe Interaction of Pralidoxime with Other Drugs

Pralidoxime should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Amoxapine

Reserpine

Morphine

Aminophylline

Pralidoxime Contraindications

If you are suffering from any of the following diseases, you should not take Pralidoxime unless your doctor advises you to do so -

Myasthenia Gravis
Kidney Disease

Frequently asked Questions about Pralidoxime

Is this Pralidoxime habit forming or addictive?

Pralidoxime is not addictive in nature.

No
Is it safe to drive or operate heavy machinery when consuming?

You may feel sleepy or tired after taking Pralidoxime. So it is best to avoid driving.

Dangerous
Is it safe?

Yes, Pralidoxime is safe but you must consult your doctor before taking it.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

No, Pralidoxime is not used to treat mental disorders.

No

Pralidoxime Interactions with Food and Alcohol

Interaction between Food and Pralidoxime

Information is not available on the interaction of any foods with Pralidoxime, due to a lack of research on this.

Unknown
Interaction between Alcohol and Pralidoxime

Due to lack of research, nothing can be said about side effects of consuming alcohol while taking Pralidoxime.

Unknown

See all substitutes for Pralidoxime

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Protopam Chloride (pralidoxime chloride)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 111

Pralidoxime Injection