Xolimus (Everolimus) is an immunosuppressant and targeted therapy used to treat various medical conditions, including certain types of cancer and organ transplant rejection. Its mechanism involves inhibiting mTOR (mammalian target of rapamycin), a key protein in cell growth and proliferation.

Uses

Cancer Treatment:

• Advanced renal cell carcinoma (kidney cancer).
• Hormone receptor-positive, HER2-negative breast cancer in postmenopausal women.
• Neuroendocrine tumors of pancreatic, gastrointestinal, or lung origin.

Organ Transplantation:

• Prevention of organ rejection in kidney and liver transplants.

Other Conditions:

• Tuberous sclerosis complex-associated conditions.

Onset of Action
The therapeutic effect of Everolimus begins within a few days to weeks, depending on the condition being treated.

Dosage and Administration

• Dosage varies by condition.
• Tablets should be taken orally, preferably at the same time each day.
• Avoid consuming grapefruit or grapefruit juice during treatment.

Side Effects

• Common: Mouth ulcers, fatigue, rash, diarrhea, and infections.
• Severe: Kidney dysfunction, lung issues, and blood sugar abnormalities.

Precautions

• Regular monitoring of blood counts, liver function, and kidney function is essential.
• Avoid use during pregnancy and breastfeeding.
• Consult a doctor if any severe side effects occur.