Dr. Bharat MBBS , General Physician

The long-term use can lead to the deficiency of Vitamin B12, which can further lead to megaloblastic anemia. Furthermore, Long-term Metformin use can also lead to kidney and liver problems. 

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Ziten M treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Ziten M induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ram Saini MD, MBBS , General Physician

Ziten M can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Dr. Joydeep Sarkar MBBS , Internal Medicine

Yes, Ziten M can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Ziten M causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Ziten M may need to be adjusted.

Dr. Mayank Yadav MBBS , General Physician

Yes, Ziten M commonly cause stomach upset like diarrhea, abdominal pain, nausea, and vomiting. To avoid these side effects you should take Ziten M with your meal and increase the dose gradually.