Dr. Vedprakash Verma MBBS, MD , Cardiology

Yes, Tenepace M is safe to use, many people have side effects at first, they usually diminish and then go away completely in a few weeks. A few people find they cannot tolerate metformin, there are other drugs but metformin is usually the first choice. It is very safe

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Tenepace M can cause some sleep problems, especially insomnia. On the other hand, Tenepace M has proven to be useful for preventing sleep apnea. The exact relationship between Tenepace M and sleep problems is still not clear, and further studies are needed for a clearer understanding.

Dr. Sameer Awadhiya MBBS , Pediatrics

Yes, you can take Tenepace M with a beta-blocker. People with diabetes tend to develop heart disease or stroke at an earlier age than the general population. One reason for this is that high glucose levels increase your risk of high blood pressure (hypertension). No harmful interactions are seen between them. However, a recent study suggests that beta-blockers can decrease the plasma level of Tenepace M and long-term use can increase lactic acid and uric acid in the blood.

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Tenepace M treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Tenepace M induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. R.K Singh MBBS , Diabetology

Yes, Tenepace M can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.