Raciwel contains Fluorouracil (5-FU), an antimetabolite and pyrimidine analog used in chemotherapy. It works by inhibiting DNA synthesis, primarily targeting rapidly dividing cancer cells.

Uses

1. Colorectal Cancer
2. Breast Cancer
3. Stomach Cancer
4. Pancreatic Cancer
5. Squamous Cell Carcinomas of the Head and Neck

​Fluorouracil is metabolized to its active form, which inhibits thymidylate synthase, leading to disruption of DNA synthesis. It also incorporates into RNA, affecting RNA function and protein synthesis.

Onset of Action

• The onset of action can be rapid to intermediate, depending on the cancer type and treatment regimen.

Duration of Action

• The therapeutic effect may last up to several weeks post-treatment.

Dosage

• Dosage varies based on the cancer type and treatment protocol.
• Colorectal Cancer (intravenous): 370 mg/m²/day for 5 consecutive days every 4 weeks or as per regimen.
• Topical Use for Skin Cancer: Apply a thin layer 1-2 times daily for 3-6 weeks or as directed by a doctor.

Common Side Effects

• Nausea, vomiting, and diarrhea
• Stomatitis (mouth sores)
• Bone marrow suppression (neutropenia, thrombocytopenia, anemia)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Alopecia (hair loss)

Precautions

• Regular monitoring of blood counts is essential.
• Use with caution in patients with impaired hepatic or renal function.
• Avoid sun exposure when using topical formulations.

Drug Interactions

• Increased toxicity risk with methotrexate.
• Enhanced myelosuppression with cisplatin.
• Caution when combining with leucovorin to enhance effectiveness but increase toxicity.

Storage

• Store below 25°C. Do not freeze. Keep away from direct sunlight.