Etovel 100mg Injection Information

Etovel (Etoposide) is a chemotherapy drug that belongs to the class of topoisomerase II inhibitors. It is widely used in the treatment of various cancers by preventing cancer cells from dividing and growing.

Uses

Small cell lung cancer (SCLC).
Testicular cancer.
Lymphomas and certain leukemias.
Ovarian and other solid tumors (off-label in some cases).

Etoposide inhibits the enzyme topoisomerase II, which is critical for DNA replication and repair. By interfering with this process, it induces DNA breaks, leading to apoptosis (programmed cell death) in rapidly dividing cancer cells.

Dosage and Administration

Small Cell Lung Cancer (SCLC): 35–50 mg/m²/day intravenously for 4–5 days or orally.
Testicular Cancer: Typically combined with other agents such as cisplatin or bleomycin.
Dosage adjustments may be necessary for patients with renal or hepatic impairment.

Side Effects

Common: Nausea, vomiting, hair loss, fatigue, low blood cell counts (anemia, leukopenia, thrombocytopenia).
Serious: Severe myelosuppression, infections, hypersensitivity reactions, secondary leukemia.

Precautions

Bone Marrow Suppression: Monitor blood counts regularly.
Infections: Avoid exposure to infections due to immunosuppression.
Pregnancy and Breastfeeding: Not recommended; can harm the fetus or infant.
Drug Interactions: Avoid using with live vaccines and drugs that interact with CYP3A4 enzymes.

Storage
Store at 15–25°C (room temperature) and protect from light. Do not freeze. Keep out of reach of children.

Etovel Benefits & Uses
Etovel Dosage & How to Take
Etovel Side Effects
Etovel Related Warnings
Etovel Contraindications
Frequently asked Questions about Etovel
Etovel Interactions with Food and Alcohol

Etovel 100mg Injection Benefits & Uses

Etovel 100mg Injection is used to treat the following -

Other Benefits

Etovel 100mg Injection Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult(Male)	Disease: Testicular Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 166 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Geriatric	Disease: Testicular Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 166 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Adult	Disease: Small Cell Lung Cancer Before or After Meal: As advised by a physician Single Maximum Dose: 50 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor

Etovel 100mg Injection Related Warnings

Is the use of Etovel 100mg Injection safe for pregnant women?

Etovel can cause severe side effects if taken during pregnancy, so, pregnant women should talk to their doctor before taking it.

Severe
Is the use of Etovel 100mg Injection safe during breastfeeding?

Women who are breastfeeding, may experience serious side effects after taking Etovel. So it is adviced to consult the doctor before using it.

Severe
What is the effect of Etovel 100mg Injection on the Kidneys?

There may be some adverse effects on kidney after taking Etovel. If you observe any such side effects, stop taking this drug. Consume this medicine again only if your doctor advises you to do so.

Moderate
What is the effect of Etovel 100mg Injection on the Liver?

The liver can be affected by Etovel. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Etovel only after medical advice.

Moderate
What is the effect of Etovel 100mg Injection on the Heart?

Using Etovel does not have any harmful effects on the heart.

Safe

Etovel 100mg Injection Contraindications

If you are suffering from any of the following diseases, you should not take Etovel 100mg Injection unless your doctor advises you to do so -

Kidney Disease
Liver Disease
Bleeding
Neutropenia

Frequently asked Questions about Etovel 100mg Injection

Is this Etovel 100mg Injection habit forming or addictive?

Etovel 100mg Injection is not addictive in nature.

No
Is it safe to drive or operate heavy machinery when consuming?

No, you should do not do anything that requires concentration and attention as the Etovel 100mg Injection can make you feel drowsy.

Dangerous
Is it safe?

Yes, but take Etovel 100mg Injection only as per medical advice.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

No, Etovel 100mg Injection cannot treat any kind of mental disorder.

No

Etovel 100mg Injection Interactions with Food and Alcohol

Interaction between Food and Etovel 100mg Injection

Taking Etovel 100mg Injection with food does not cause any problems.

Safe
Interaction between Alcohol and Etovel 100mg Injection

No research has been done on this till date. Therefore, it is not known what the effect of taking Etovel 100mg Injection with alcohol will be.

Unknown

See all substitutes for Etovel

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Etopophos® (etoposide phosphate)

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 866

Etovel 100mg Injection