Adcov Injection by Adley Pharmaceuticals contains leucovorin calcium, also known as calcium folinate. It is a reduced form of folic acid that serves critical roles in cancer therapy and as a rescue agent in methotrexate toxicity. Leucovorin calcium is a vital component in oncology and hematology, enhancing chemotherapeutic efficacy and countering folate antagonist toxicity.

Composition:

• Active Ingredient: Leucovorin Calcium (available in varying strengths such as 10 mg, 50 mg, or 100 mg per vial).

• Form: Lyophilized powder for injection or ready-to-use injectable solution.

• Route of Administration: Intravenous (IV) or Intramuscular (IM).

Indications:

Methotrexate Rescue Therapy:

• Prevents or mitigates toxic effects of high-dose methotrexate therapy in cancer patients.

Combination Therapy with 5-Fluorouracil (5-FU):

• Enhances the efficacy of 5-FU in the treatment of colorectal and other cancers.

Folate Deficiency and Megaloblastic Anemia:

• Treats anemias caused by folate deficiency.

Antidote for Folate Antagonist Overdose:

• Reverses toxicity caused by drugs like trimethoprim, pyrimethamine, and methotrexate.

Leucovorin calcium bypasses the dihydrofolate reductase enzyme, directly replenishing tetrahydrofolate. This action:

1. Supports DNA, RNA, and protein synthesis in rapidly dividing cells.

2. Stabilizes the thymidylate synthase and 5-FU complex, increasing the cytotoxic effects of 5-FU on cancer cells.

3. Counteracts the toxicity of folate antagonists by replenishing active folate stores.