Azakem Information

Azakem is an antineoplastic agent that works as a hypomethylating agent. It is primarily used in the treatment of certain types of myelodysplastic syndromes (MDS), a group of bone marrow disorders. Azakem helps restore normal gene function, promoting healthy blood cell production and inhibiting the growth of abnormal cells in the bone marrow.

Indications:

Myelodysplastic Syndromes (MDS):
- Refractory anemia or anemia with excess blasts.
- Chronic myelomonocytic leukemia (CMML).
- Intermediate-2 and high-risk MDS based on the International Prognostic Scoring System (IPSS).
Acute Myeloid Leukemia (AML):
- For patients with AML who are not candidates for intensive chemotherapy.

Azakem incorporates into DNA and RNA, inhibiting DNA methyltransferase. This results in hypomethylation of DNA and reactivation of silenced tumor suppressor genes. The drug also disrupts RNA processing, which may contribute to its anti-cancer effects. These mechanisms slow or stop the growth of abnormal cells and promote normal cell development.

Azakem Benefits & Uses
Azakem Dosage & How to Take
Azakem Side Effects
Azakem Related Warnings
Severe Interaction of Azakem with Other Drugs
Azakem Contraindications
Frequently asked Questions about Azakem
Azakem Interactions with Food and Alcohol

Azakem Benefits & Uses

Azakem is used to treat the following -

Main Benefits

Blood Cancer

Other Benefits

Myelodysplastic Syndrome

Azakem Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult	Disease: Myelodysplastic Syndrome Before or After Meal: Either Single Maximum Dose: 125 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Geriatric	Disease: Myelodysplastic Syndrome Before or After Meal: Either Single Maximum Dose: 125 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor

Azakem Side Effects

Based on research, the following side effects have been observed when Azakem is used -

Severe

Nausea or vomiting
Decreased potassium level in blood
Nasopharyngitis
Anemia (Read More - Home Remedies for Anaemia)
Constipation (Read More - Home remedies for constipation)
Bleeding

Moderate

Erythema

Mild

Headache
Dizziness (Read More - Home Remedies for Dizziness: Quick Tips for Instant Relief)
Insomnia
Loss of appetite
Diarrhoea
Injection Site Allergic Reaction
Urticaria
Chest Pain

Common

Mouth ulcer (Read More - How to get rid of Mouth Ulcers)
Decreased Blood Cells (Red cells, White cells and Platelets)

Azakem Related Warnings

Is the use of Azakem safe for pregnant women?

Severe
Is the use of Azakem safe during breastfeeding?

Severe
What is the effect of Azakem on the Kidneys?

Mild
What is the effect of Azakem on the Liver?

Mild
What is the effect of Azakem on the Heart?

Mild

Severe Interaction of Azakem with Other Drugs

Azakem should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Adalimumab

Azakem Contraindications

If you are suffering from any of the following diseases, you should not take Azakem unless your doctor advises you to do so -

Liver Cancer
Kidney Disease
Liver Disease
Anemia

Frequently asked Questions about Azakem

Is this Azakem habit forming or addictive?

No
Is it safe to drive or operate heavy machinery when consuming?

Dangerous
Is it safe?

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

No

Azakem Interactions with Food and Alcohol

Interaction between Food and Azakem

Unknown
Interaction between Alcohol and Azakem

Unknown

See all substitutes for Azakem

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Vidaza (azacitidine)

Therapeutic Goods Administration (TGA): Department of Health [Internet]. Governmet of Australia; Package leaflet information for the user; Celazadine® (azacitidine)

Azakem 100mg Injection