Amitant 150mg Injection

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₹ 2585
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Amitant 150mg Injection

1 Injection in 1 Vial
₹ 2585
1 Injection | 1 Vial
₹ 2585
people have bought this recently

Amitant Information

Amitant contains Fosaprepitant, a neurokinin-1 (NK1) receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting caused by chemotherapy. Fosaprepitant is the prodrug of aprepitant, which works by blocking the effects of substance P, a neurotransmitter involved in vomiting reflex.

Uses

Chemotherapy-Induced Nausea and Vomiting (CINV):

  • Used in combination with other antiemetics for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy.

Postoperative Nausea and Vomiting (PONV):

  • Used for the prevention of postoperative nausea and vomiting in patients undergoing surgery.

Fosaprepitant is rapidly converted to aprepitant in the body, which selectively inhibits the neurokinin-1 receptor. This blockage prevents the action of substance P in the central nervous system, thereby reducing nausea and vomiting.

Onset of Action

  • The onset of action of Fosaprepitant is typically within 1-3 hours after administration.

Duration of Action

  • The effects last for up to 24 to 72 hours, depending on the type of chemotherapy or surgery.

Dosage

Chemotherapy-Induced Nausea and Vomiting (CINV):

  • IV dose: 150 mg administered intravenously 30 minutes before the chemotherapy session on Day 1.
  • May be followed by oral aprepitant for 2 additional days.

Postoperative Nausea and Vomiting (PONV):

  • IV dose: 150 mg administered as a single dose 1 hour before anesthesia induction.

Common Side Effects

  • Fatigue
  • Constipation
  • Decreased appetite
  • Headache
  • Liver enzyme elevations
  • Hypersensitivity reactions (rare)

Precautions

  • Caution in patients with liver impairment (dose adjustment required).
  • Monitor for potential drug interactions, particularly with drugs metabolized by the cytochrome P450 enzyme system (e.g., warfarin, dexamethasone).

Drug Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole): Can increase Fosaprepitant levels.
  • CYP3A4 inducers (e.g., rifampin): Can decrease Fosaprepitant levels.
  • Warfarin: Fosaprepitant can alter INR (International Normalized Ratio).
  • Dexamethasone: May require dose adjustment due to interaction.

Storage

  • Store at room temperature (20-25°C) in a tightly closed container. Do not freeze.


Amitant Benefits & Uses

Amitant is used to treat the following -

Amitant Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 150 mg
  • Dosage Route: Parenteral
  • Frequency: doctor administered
  • Course Duration: As directed by the doctor
  • Special Instructions: used in highly emetogenic cancer chemotherapy
Geriatric
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 150 mg
  • Dosage Route: Parenteral
  • Frequency: doctor administered
  • Course Duration: As directed by the doctor
  • Special Instructions: used in highly emetogenic cancer chemotherapy
13 - 18 years (Adolescent)
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 150 mg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: 1 days
  • Special Instructions: used in highly emetogenic cancer chemotherapy
2 - 12 years (Child)
  • Disease: Nausea and Vomiting
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 4 mg/kg
  • Dosage Route: Parenteral
  • Frequency: once only
  • Course Duration: 1 days
  • Special Instructions: used in highly emetogenic cancer chemotherapy


Amitant Side Effects

Based on research, the following side effects have been observed when Amitant is used -

Moderate

Mild

Common

  • Loss of appetite

Amitant Related Warnings

  • Is the use of Amitant safe for pregnant women?


    There are no side effects of Amitant in pregnant women.

    Safe
  • Is the use of Amitant safe during breastfeeding?


    Women who are breastfeeding can experience some moderate side effects of Amitant. Immediately discontinue Amitant if you observe any side effects. Contact your doctor, and restart using it only if your doctor considers it safe for you.

    Moderate
  • What is the effect of Amitant on the Kidneys?


    Amitant is completely safe for kidneys.

    Safe
  • What is the effect of Amitant on the Liver?


    Very few cases of side effects of Amitant on the liver have been reported.

    Mild
  • What is the effect of Amitant on the Heart?


    Using Amitant does not have any harmful effects on the heart.

    Safe


Severe Interaction of Amitant with Other Drugs

Amitant should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Chlorpheniramine,Dextromethorphan,Paracetamol,Phenylephrine
    Lurasidone

    Moderate



    Amitant Contraindications

    If you are suffering from any of the following diseases, you should not take Amitant unless your doctor advises you to do so -



    Frequently asked Questions about Amitant

    • Is this Amitant habit forming or addictive?


      Forming a habit of Amitant has not been reported.

      No
    • Is it safe to drive or operate heavy machinery when consuming?


      You may feel sleepy or tired after taking Amitant. So it is best to avoid driving.

      Dangerous
    • Is it safe?


      Yes, Amitant is safe but you must consult your doctor before taking it.

      Safe, but take only on Doctor's advise
    • Is it able to treat mental disorders?


      No, Amitant is not used to treat mental disorders.

      No

    Amitant Interactions with Food and Alcohol

    • Interaction between Food and Amitant


      Taking Amitant with food does not harm your health.

      Safe
    • Interaction between Alcohol and Amitant


      It is difficult to say anything about the effect of Amitant and alcohol. No research has been done on this yet.

      Unknown


    See all substitutes for Amitant


    This medicine data has been created by -

    Vikas Chauhan

    B.Pharma, Pharmacy
    5 Years of Experience


    References

    US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Emend (fosaprepitant)

    April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 180-182



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