Decintas Information

Decintas (Decitabine) is a chemotherapy drug belonging to the class of hypomethylating agents. It is primarily used for treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Decitabine works by inhibiting DNA methylation, which can reactivate genes responsible for normal cell growth and differentiation.

Uses

Myelodysplastic Syndromes (MDS):

Used in the treatment of patients with MDS, including refractory anemia, chronic myelomonocytic leukemia (CMML), and other related conditions.

Acute Myeloid Leukemia (AML):

Effective in treating newly diagnosed AML, especially in older patients who are not candidates for intensive chemotherapy.

Decitabine incorporates into the DNA during replication and inhibits DNA methyltransferases. This leads to hypomethylation of DNA, allowing re-expression of tumor-suppressor genes and inhibiting the proliferation of cancer cells.

Decintas Benefits & Uses
Decintas Dosage & How to Take
Decintas Side Effects
Decintas Related Warnings
Severe Interaction of Decintas with Other Drugs
Decintas Contraindications
Frequently asked Questions about Decintas
Decintas Interactions with Food and Alcohol

Decintas Benefits & Uses

Decintas is used to treat the following -

Main Benefits

Myelodysplastic Syndrome

Decintas Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult	Disease: Myelodysplastic Syndrome Before or After Meal: As advised by a physician Single Maximum Dose: 50 mg Dosage Route: Parenteral Frequency: 1 daily Course Duration: 5 days Special Instructions: Given as a continuous intravenous infusion over 1 hour

Decintas Side Effects

Based on research, the following side effects have been observed when Decintas is used -

Moderate

Decreased white blood cell count (neutrophils)
Anemia (Read More - Home Remedies for Anaemia)
Reduced blood platelets
Edema
Erythema
Confusion

Mild

Nausea or vomiting
Headache
Fever (Read More - Home remedies for fever)
Infection
Nosebleed (Read More - How to stop a nosebleed)
Diarrhoea

Common

Pneumonitis

Decintas Related Warnings

Is the use of Decintas safe for pregnant women?

Decintas shows severe side effect on pregnant women. For this reason, pregnant women should only take it after taking medical advice.

Severe
Is the use of Decintas safe during breastfeeding?

Due to lack of research work on this topic, the side effects of Decintas for breastfeeding women are not known.

Unknown
What is the effect of Decintas on the Kidneys?

There may be some adverse effects on kidney after taking Decintas. If you observe any such side effects, stop taking this drug. Consume this medicine again only if your doctor advises you to do so.

Moderate
What is the effect of Decintas on the Liver?

The liver can be affected by Decintas. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Decintas only after medical advice.

Moderate
What is the effect of Decintas on the Heart?

Decintas may have mild side effects on the heart. Most people will never see any effect on the heart.

Mild

Severe Interaction of Decintas with Other Drugs

Decintas should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Celecoxib

Clozapine

Diclofenac

Moderate

Warfarin

Azathioprine

Apixaban

Decintas Contraindications

If you are suffering from any of the following diseases, you should not take Decintas unless your doctor advises you to do so -

Anemia
Fungal Infections
Kidney Disease
Liver Disease
Allergy

Frequently asked Questions about Decintas

Is this Decintas habit forming or addictive?

Decintas does not cause addiction.

No
Is it safe to drive or operate heavy machinery when consuming?

Yes, you can comfortably use machinery or drive after taking Decintas since it will not make you feel sleepy.

Safe
Is it safe?

Yes, Decintas is safe but you must consult your doctor before taking it.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

Decintas is unable to treat or cure mental disorders.

No

Decintas Interactions with Food and Alcohol

Interaction between Food and Decintas

There is no information on the effects of taking Decintas with food, because this topic has not been scientifically researched yet.

Unknown
Interaction between Alcohol and Decintas

No research has been done on this till date. Therefore, it is not known what the effect of taking Decintas with alcohol will be.

Unknown

See all substitutes for Decintas

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Dacogen® (decitabine)

Decintas 30mg Injection