Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Pioglar MF treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Pioglar MF induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Sameer Awadhiya MBBS , Pediatrics

Yes, you can take Pioglar MF with a beta-blocker. People with diabetes tend to develop heart disease or stroke at an earlier age than the general population. One reason for this is that high glucose levels increase your risk of high blood pressure (hypertension). No harmful interactions are seen between them. However, a recent study suggests that beta-blockers can decrease the plasma level of Pioglar MF and long-term use can increase lactic acid and uric acid in the blood.

Dr. R.K Singh MBBS , Diabetology

Yes, Pioglar MF can be taken with the statin. There is no serious or harmful interaction have been observed between them. Some studies say that it's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.

Dr. Mayank Yadav MBBS , General Physician

Yes, Pioglar MF commonly cause stomach upset like diarrhea, abdominal pain, nausea, and vomiting. To avoid these side effects you should take Pioglar MF with your meal and increase the dose gradually.

Dr. Ramraj MBBS , Other

Yes, Pioglar MF can cause low blood sugar (hypoglycemia). However, this can also occur if you delay or miss a meal, drink alcohol, exercise more than usual, can't eat due to stomach upset, and taking other antidiabetic medicine with metformin. So, regular monitoring of blood glucose level is needed and be cautious of symptoms of hypoglycemia, always keep glucose-rich food with you.