Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Pichromet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Pichromet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Sameer Awadhiya MBBS , Pediatrics

Pichromet increases the sensitivity of insulin, young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. It is often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan.

Dr. Vipin Khadse MBBS , General Physician

Pichromet is not a known cause of alopecia (hair loss). However, the conditions treated by Pichromet type 2 diabetes and PCOS, often list hair loss as a possible symptom.

Dr. Vedprakash Verma MBBS, MD , Cardiology

Yes, Pichromet is safe to use, many people have side effects at first, they usually diminish and then go away completely in a few weeks. A few people find they cannot tolerate metformin, there are other drugs but metformin is usually the first choice. It is very safe

Dr. Ashish Mishra MBBS , Pathology

Yes, you can take Pichromet with gliclazide, no harmful interactions have been reported between them. However, it is not necessary that no interaction can happen between these two. But before taking such kind of combination you must consult your doctor.