Pazroto 400mg Tablet

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Pazroto 400mg Tablet

30 Tablet in 1 Bottle
₹ 10500
30 Tablet | 1 Bottle
₹ 10500
0 people have bought this recently
myUpchar Recommended - 98% more Savings
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Pazroto 400mg Tablet Information

Pazroto, contains Pazopanib, is an oral medication primarily used in the treatment of advanced renal cell carcinoma and soft tissue sarcomas. As a multi-targeted receptor tyrosine kinase inhibitor, it impedes tumor growth and angiogenesis by targeting specific enzymes.

Medical Uses

  • Advanced Renal Cell Carcinoma (RCC): It is utilized in patients with advanced stages of RCC to slow disease progression.

  • Advanced Soft Tissue Sarcomas: Indicated for patients who have received prior chemotherapy, Pazopanib offers therapeutic benefits in managing these malignancies.

Additionally, Pazopanib has shown potential in treating aggressive fibromatosis (desmoid tumors) and has been explored in ovarian and non-small cell lung cancers. However, its application in ovarian cancer has not received regulatory approval.

Mechanism of Action

Pazopanib functions by inhibiting multiple tyrosine kinases, including:

  • Vascular Endothelial Growth Factor Receptors (VEGFR) 1, 2, and 3: These receptors play a crucial role in angiogenesis, the formation of new blood vessels that supply tumors.

  • Platelet-Derived Growth Factor Receptors (PDGFR) α and β: Involved in cell growth and survival.

  • c-KIT: A receptor implicated in cell proliferation.

By targeting these receptors, Pazopanib disrupts pathways essential for tumor growth and vascularization.

Administration and Dosage

Pazopanib is administered orally in tablet form, taken on an empty stomach—either at least one hour before or two hours after a meal—to enhance absorption. Tablets should be swallowed whole without splitting, chewing, or crushing. Dosage adjustments may be necessary based on individual patient response and tolerability.

Pharmacokinetics

  • Absorption: Pazopanib has an oral bioavailability of approximately 21%, with peak plasma concentrations reached around 3.5 hours post-administration.

  • Distribution: Over 99.5% of Pazopanib binds to plasma proteins.

  • Metabolism: Primarily metabolized in the liver by the CYP3A4 enzyme, with minor contributions from CYP1A2 and CYP2C8.

  • Elimination: The drug has a mean half-life of about 30.9 hours and is excreted mainly via feces, with less than 4% eliminated through urine.

Contraindications and Precautions

Pazopanib is contraindicated in individuals with known hypersensitivity to the drug or its components. Caution is advised in patients with:

  • Hepatic Impairment: Severe liver toxicity, including fatalities, has been reported. Regular liver function monitoring is essential.

  • Hypertension: Elevations in blood pressure, including hypertensive crises, have occurred. Blood pressure should be well-controlled prior to initiating treatment and monitored regularly.

  • QT Interval Prolongation: Pazopanib can prolong the QT interval, increasing the risk of torsades de pointes. Electrocardiograms and electrolyte monitoring are recommended.

  • Thrombotic Events: Arterial and venous thrombotic events, including myocardial infarction and cerebrovascular accidents, have been observed.

  • Hemorrhagic Events: Severe bleeding, including fatal cases, has been reported.

  • Gastrointestinal Perforations and Fistulas: Cases of gastrointestinal perforation and fistula formation have been noted.

Due to the risk of hepatotoxicity, liver function tests should be conducted before starting treatment and monitored periodically thereafter.

Adverse Effects

Common side effects include:

  • Diarrhea

  • Hypertension

  • Hair color changes

  • Nausea

  • Anorexia

  • Fatigue

  • Elevated liver enzymes

Serious adverse effects encompass hepatotoxicity, QT prolongation, hemorrhagic events, and thrombotic events. Patients should be closely monitored, and any severe or persistent adverse reactions should prompt reevaluation of therapy.

Drug Interactions

Pazopanib's metabolism via CYP3A4 makes it susceptible to interactions:

  • CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): May increase Pazopanib levels, elevating the risk of toxicity.

  • CYP3A4 Inducers (e.g., rifampin): Can decrease Pazopanib levels, potentially reducing efficacy.

Concomitant use of acid-reducing agents (e.g., proton pump inhibitors, H2 antagonists) may affect Pazopanib absorption. St. John's wort may decrease Pazopanib levels and should be avoided.



Pazroto 400mg Tablet Benefits & Uses

Pazroto 400mg Tablet is used to treat the following -

Other Benefits

Pazroto 400mg Tablet Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Kidney Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 800 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: For course duration follow doctor's advice
Geriatric
  • Disease: Kidney Cancer
  • Before or After Meal: Either
  • Single Maximum Dose: 800 mg
  • Dosage Form: Tablet
  • Dosage Route: Oral
  • Frequency: 1 daily
  • Course Duration: As directed by the doctor
  • Special Instructions: For course duration follow doctor's advice

Pazroto 400mg Tablet Related Warnings

  • Is the use of Pazroto 400mg Tablet safe for pregnant women?


    Pazroto has many dangerous side effects in pregnant women. If you are pregnant, do not consume Pazroto without medical advice.

    Severe
  • Is the use of Pazroto 400mg Tablet safe during breastfeeding?


    Due to lack of research work on this topic, the side effects of Pazroto for breastfeeding women are not known.

    Unknown
  • What is the effect of Pazroto 400mg Tablet on the Kidneys?


    There can be some harmful effects on your kidneys after taking Pazroto. If you witness any side effects, discontinue its use. Consult your medical practitioner, do as he/she suggests.

    Moderate
  • What is the effect of Pazroto 400mg Tablet on the Liver?


    The liver can be affected by Pazroto. If you experience any unwanted effects of this drug, stop taking it and consult your doctor. You should restart Pazroto only after medical advice.

    Moderate
  • What is the effect of Pazroto 400mg Tablet on the Heart?


    Pazroto can have moderate side effects on the heart. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate


Severe Interaction of Pazroto 400mg Tablet with Other Drugs

Pazroto 400mg Tablet should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

Moderate



Pazroto 400mg Tablet Contraindications

If you are suffering from any of the following diseases, you should not take Pazroto 400mg Tablet unless your doctor advises you to do so -



Frequently asked Questions about Pazroto 400mg Tablet

  • Is this Pazroto 400mg Tablet habit forming or addictive?


    Pazroto 400mg Tablet is not addictive in nature.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    Yes, it is safe to do these activities or work after taking Pazroto 400mg Tablet as it does not make you drowsy.

    Safe
  • Is it safe?


    Yes, but take Pazroto 400mg Tablet only as per medical advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Pazroto 400mg Tablet is not used to treat mental disorders.

    No

Pazroto 400mg Tablet Interactions with Food and Alcohol

  • Interaction between Food and Pazroto 400mg Tablet


    There isn't any research available on the side effects of taking Pazroto 400mg Tablet with food.

    Unknown
  • Interaction between Alcohol and Pazroto 400mg Tablet


    Consuming Pazroto 400mg Tablet with alcohol can have many serious effects on your body.

    Severe


See all substitutes for Pazroto



This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience



References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 990-991

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Votrient (pazopanib)



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