Oplatin 50mg Injection

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25ml Injection in 1 Vial
₹ 2021 ₹2501.25 19% OFF Save: ₹480
25ml Injection 1 Vial ₹ 2021 ₹2501.25 19% OFF Save: ₹480
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Oplatin 50mg Injection

25ml Injection in 1 Vial
₹ 2021 ₹2501 19% OFF Save: ₹480
25ml Injection | 1 Vial
₹ 2021 ₹2501 19% OFF Save: ₹480
0 people have bought this recently

Oplatin 50mg Injection Information

Oplatin Injection contains Oxaliplatin, a platinum-based chemotherapy drug used to treat colon and rectal cancers. It works by inhibiting the growth of cancer cells.

Uses:

  • Treatment of colon and rectal cancer.

Oxaliplatin is a platinum-based chemotherapy drug that exerts its anticancer effects by interfering with the DNA of cancer cells. The mechanism of action involves the following steps:

  1. DNA Intercalation and Crosslinking: Oxaliplatin is taken up by the cancer cell and undergoes conversion into its active form. It binds to the DNA in the cell, creating both intra- and inter-strand crosslinks in the DNA structure.

  2. Inhibition of DNA Replication and Transcription: These crosslinks prevent the DNA from unwinding and replicating properly, which interferes with the cell's ability to replicate its genetic material and divide. This leads to the inhibition of DNA replication and transcription.

  3. Induction of Apoptosis: The DNA damage caused by oxaliplatin triggers cellular mechanisms that induce programmed cell death (apoptosis). This process ultimately kills the cancer cell and helps to control tumor growth.

  4. Platinum-DNA Adduct Formation: Oxaliplatin forms platinum-DNA adducts, which are highly cytotoxic. These adducts further prevent proper cell division and cause cell cycle arrest at various checkpoints.

Oxaliplatin is particularly effective in treating colorectal cancer due to its ability to damage cancerous cells, leading to their death and preventing tumor progression.

Dosage and Administration:

Oplatin Injection is administered intravenously by a qualified healthcare professional. The dosage and frequency are determined by the treating physician based on the patient's condition. It is crucial to follow the doctor's instructions precisely to avoid serious side effects.

Common Side Effects:

  • Nausea
  • Fatigue
  • Vomiting
  • Diarrhea
  • Anemia (low red blood cell count)
  • Decreased white blood cell count
  • Low blood platelets
  • Increased liver enzymes
  • Peripheral neuropathy (tingling and numbness in hands and feet)
  • Stomatitis (inflammation of the mouth)

Most side effects do not require medical attention and may subside as the body adjusts to the medication. However, consult your doctor if they persist or cause concern.

Warnings and Precautions:

  • Alcohol: It is not known whether it is safe to consume alcohol with Oxaliplatin Injection. Please consult your doctor.
  • Pregnancy: Oxaliplatin Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may prescribe it in some life-threatening situations if the benefits outweigh the risks. Please consult your doctor.
  • Breastfeeding: Oxaliplatin Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
  • Driving: Oxaliplatin Injection may cause side effects that could affect your ability to drive. Treatment may result in an increased risk of dizziness, nausea, vomiting, and other neurological symptoms that affect walking, which may impair your ability to drive.
  • Kidney: Oxaliplatin Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed. Please consult your doctor.
  • Liver: Oxaliplatin Injection should be used with caution in patients with liver disease. Dose adjustment may be needed. Please consult your doctor.

Storage:

Store in a refrigerator (2°C – 8°C). Do not freeze. Keep the vial in the outer carton to protect from light.



Oplatin 50mg Injection Benefits & Uses

Oplatin 50mg Injection is used to treat the following -

Other Benefits

Oplatin 50mg Injection Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage
Adult
  • Disease: Colorectal Cancer
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 140 mg
  • Dosage Route: Parenteral
  • Frequency: doctor administered
  • Course Duration: 6 months
  • Special Instructions: Given 85 mg/m2 as IV infusion with combination of 5-fluorouracil/leucovorin in every 2 weeks
Geriatric
  • Disease: Colorectal Cancer
  • Before or After Meal: As advised by a physician
  • Single Maximum Dose: 140 mg
  • Dosage Route: Parenteral
  • Frequency: doctor administered
  • Course Duration: 6 months
  • Special Instructions: Given 85 mg/m2 as IV infusion with combination of 5-fluorouracil/leucovorin in every 2 weeks


Oplatin 50mg Injection Side Effects

Based on research, the following side effects have been observed when Oplatin 50mg Injection is used -

Severe

Moderate

  • Increased Liver Enzymes
  • Stomatitis (Inflammation of the mouth)

Mild

Oplatin 50mg Injection Related Warnings

  • Is the use of Oplatin 50mg Injection safe for pregnant women?


    Oplatin has many dangerous side effects in pregnant women. If you are pregnant, do not consume Oplatin without medical advice.

    Severe
  • Is the use of Oplatin 50mg Injection safe during breastfeeding?


    Women who are breastfeeding may experience severe harmful effects after taking Oplatin. It should only be taken after medical advice.

    Severe
  • What is the effect of Oplatin 50mg Injection on the Kidneys?


    Oplatin rarely harms the kidneys.

    Mild
  • What is the effect of Oplatin 50mg Injection on the Liver?


    Oplatin may cause harmful effects on liver. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.

    Moderate
  • What is the effect of Oplatin 50mg Injection on the Heart?


    You may experience side effects on your heart after taking Oplatin. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.

    Moderate


Oplatin 50mg Injection Contraindications

If you are suffering from any of the following diseases, you should not take Oplatin 50mg Injection unless your doctor advises you to do so -



Frequently asked Questions about Oplatin 50mg Injection

  • Is this Oplatin 50mg Injection habit forming or addictive?


    Forming a habit of Oplatin 50mg Injection has not been reported.

    No
  • Is it safe to drive or operate heavy machinery when consuming?


    You may feel sleepy or tired after taking Oplatin 50mg Injection. So it is best to avoid driving.

    Dangerous
  • Is it safe?


    Oplatin 50mg Injection should be used only after doctor's advice.

    Safe, but take only on Doctor's advise
  • Is it able to treat mental disorders?


    No, Oplatin 50mg Injection is not used to treat mental disorders.

    No

Oplatin 50mg Injection Interactions with Food and Alcohol

  • Interaction between Food and Oplatin 50mg Injection


    You can take Oplatin 50mg Injection with food.

    Safe
  • Interaction between Alcohol and Oplatin 50mg Injection


    Consuming Oplatin 50mg Injection with alcohol can have many serious effects on your body.

    Severe


See all substitutes for Oplatin



This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience



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