Dr. Joydeep Sarkar MBBS , Internal Medicine

Yes, Metsafe can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Metsafe causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Metsafe may need to be adjusted.

Dr. Ram Saini MD, MBBS , General Physician

Metsafe can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Metsafe treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metsafe induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Metsafe works by decreasing the hepatic glucose production. It also works to lower blood sugar by increasing your sensitivity to insulin and decreasing the amount of glucose that is absorbed from the food you eat.

Dr. Mayank Yadav MBBS , General Physician

Yes, Metsafe commonly cause stomach upset like diarrhea, abdominal pain, nausea, and vomiting. To avoid these side effects you should take Metsafe with your meal and increase the dose gradually.