Methotrexate

Yes, Methotrexate may cause anemia, this occurs only in a few cases. It is a rare side effect of this drug. It occurs due to bone marrow suppression which might cause anemia (low red blood cells count), leukopenia (low white blood cells count), thrombocytopenia (low platelets count), and pancytopenia (low red cells, white cells, and platelets). However, this effect is reversible in nature and the function of bone marrow is restored after discontinuation of this drug.

The dosage of this drug may vary depending on the diagnosis and the patient's medical condition. Take Methotrexate as advised by your doctor. Ideally, oral Methotrexate has to be taken empty stomach because the presence of food might affect the absorption of this drug from the stomach. Precautions must be taken in patients with bone marrow depression, and improper liver or kidney function.

Methotrexate contains methotrexate which is a chemotherapy drug that works in cancer by preventing the DNA synthesis of cancerous cells. It inhibits dihydrofolic acid reductase enzyme which is important for the formation of tetrahydrofolate. Tetrahydrofolate is essential for the synthesis of some DNA components of the cancerous cells. Incase of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis, and Crohn's disease Methotrexate works by suppressing the body's normal immune response to inflammation. This results in reduced inflammation and provides relief from the symptoms associated with these diseases.

Rarely, Methotrexate causes fever and chills. If you are experiencing a fever after taking this drug then discuss it with your doctor and follow his/her instructions.

Yes Methotrexate can be taken with paracetamol. Paracetamol does not appear to interfere with the efficacy of Methotrexate. Hence, it is alright to take them together. However, if you feel any discomfort after taking this drug do not hesitate to inform your doctor.