ravi udawat MBBS , General Physician

Metchek should be taken with food to reduce stomach and bowel side effects, which may experience the first few weeks of treatment. Also, exercise regularly and test for sugar in your blood or urine as directed.

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Metchek treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Metchek induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ram Saini MD, MBBS , General Physician

Metchek can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Dr. Bharat MBBS , General Physician

The long-term use can lead to the deficiency of Vitamin B12, which can further lead to megaloblastic anemia. Furthermore, Long-term Metformin use can also lead to kidney and liver problems. 

Dr. Joydeep Sarkar MBBS , Cardiology, Neurology, Pulmonology, Nephrology, Hepatology, Internal Medicine, Diabetology

Yes, Metchek can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Metchek causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Metchek may need to be adjusted.