Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Mesite treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Mesite induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Mesite can cause some sleep problems, especially insomnia. On the other hand, Mesite has proven to be useful for preventing sleep apnea. The exact relationship between Mesite and sleep problems is still not clear, and further studies are needed for a clearer understanding.

Dr. Sameer Awadhiya MBBS , Pediatrics

Mesite increases the sensitivity of insulin, young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. It is often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan.

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Mesite works by decreasing the hepatic glucose production. It also works to lower blood sugar by increasing your sensitivity to insulin and decreasing the amount of glucose that is absorbed from the food you eat.

Dr. Ramraj MBBS , Other

Yes, Mesite can cause low blood sugar (hypoglycemia). However, this can also occur if you delay or miss a meal, drink alcohol, exercise more than usual, can't eat due to stomach upset, and taking other antidiabetic medicine with metformin. So, regular monitoring of blood glucose level is needed and be cautious of symptoms of hypoglycemia, always keep glucose-rich food with you.