Dr. Sameer Awadhiya MBBS , Pediatrics

Mastero increases the sensitivity of insulin, young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. It is often prescribed for women with PCOS to help prevent diabetes. A lifestyle that includes healthy nutrition and daily exercise is the most important part of a PCOS treatment plan.

Dr. Ram Saini MD, MBBS , General Physician

Mastero can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Dr. Vipin Khadse MBBS , General Physician

Mastero is not a known cause of alopecia (hair loss). However, the conditions treated by Mastero type 2 diabetes and PCOS, often list hair loss as a possible symptom.

Dr. Sameer Awadhiya MBBS , Pediatrics

Mastero helps in weight loss by reducing appetite and food intake. It also increases the insulin sensitivity in your body to work more effectively. This lead to decreased glucose production increases the use of glucose and decrease the fat deposition further helps in weight loss. However, Mastero is not approved for weight loss, this is an off-label use.

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Mastero treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Mastero induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst.