Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Daophage treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Daophage induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ashish Mishra MBBS , Pathology

Yes, you can take Daophage with gliclazide, no harmful interactions have been reported between them. However, it is not necessary that no interaction can happen between these two. But before taking such kind of combination you must consult your doctor.

Dr. Manju Shekhawat MBBS , General Physician

No, you should not take alcohol with Daophage, because it can cause serious side effects which includes hypoglycemia (low blood sugar). The risk of hypoglycemia is higher when you're drinking and taking Daophage than if you're just taking Daophage. Some of the signs of hypoglycemia include dizziness, confusion, and drowsiness.

Dr. Joydeep Sarkar MBBS , Cardiology, Neurology, Pulmonology, Nephrology, Hepatology, Internal Medicine, Diabetology

Yes, Daophage can cause night sweat, the exact mechanism of sweating is not known. But some research suggests that Daophage causes hypoglycemia (low blood sugar) especially at night which can cause night sweats. Need to monitor your blood glucose level regularly, and talk to your doctor as your dose of Daophage may need to be adjusted.

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Daophage can cause some sleep problems, especially insomnia. On the other hand, Daophage has proven to be useful for preventing sleep apnea. The exact relationship between Daophage and sleep problems is still not clear, and further studies are needed for a clearer understanding.