Dr. Sameer Awadhiya MBBS , Pediatrics

Chromet helps in weight loss by reducing appetite and food intake. It also increases the insulin sensitivity in your body to work more effectively. This lead to decreased glucose production increases the use of glucose and decrease the fat deposition further helps in weight loss. However, Chromet is not approved for weight loss, this is an off-label use.

Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Chromet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Chromet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ayush Pandey MBBS, PG Diploma , General Physician

Yes, Chromet can cause some sleep problems, especially insomnia. On the other hand, Chromet has proven to be useful for preventing sleep apnea. The exact relationship between Chromet and sleep problems is still not clear, and further studies are needed for a clearer understanding.

Dr. Bharat MBBS , General Physician

The long-term use can lead to the deficiency of Vitamin B12, which can further lead to megaloblastic anemia. Furthermore, Long-term Metformin use can also lead to kidney and liver problems. 

Dr. Mayank Yadav MBBS , General Physician

Yes, Chromet commonly cause stomach upset like diarrhea, abdominal pain, nausea, and vomiting. To avoid these side effects you should take Chromet with your meal and increase the dose gradually.