Epribenz, containing Epirubicin as the active ingredient, is an anthracycline chemotherapy drug. It is widely used in the treatment of various types of cancers. Epirubicin works by interfering with the DNA of cancer cells, thereby preventing their growth and multiplication.

Uses:

1. Breast cancer.
2. Gastric (stomach) cancer.
3. Bladder cancer.
4. Lung cancer.
5. Ovarian cancer.

Epirubicin binds to the DNA of cancer cells, preventing the replication of genetic material. It also inhibits the enzyme topoisomerase II, causing DNA strand breaks and leading to cell death.

Dosage and Administration:

Dosage:

• Breast cancer: 100–120 mg/m² in divided doses.
• Other cancers: Dose varies depending on cancer type and patient’s condition.

Administered via intravenous (IV) infusion under the supervision of a healthcare professional.

Side Effects:
Common side effects:

• Nausea and vomiting.
• Hair loss (alopecia).
• Fatigue.
• Low blood cell counts (anemia, neutropenia).
• Mouth sores.

Serious side effects:

• Heart damage (cardiotoxicity).
• Risk of secondary leukemia.
• Severe allergic reactions.

Precautions:

• Regular monitoring of heart function is essential to avoid cardiotoxicity.
• Not recommended for use during pregnancy or breastfeeding.
• Dose adjustments may be necessary for patients with liver or kidney impairment.
• Avoid live vaccines during treatment.

Storage Instructions:

• Store at 2–8°C.
• Protect from light and avoid freezing.