Dr. Madhur Anand MBBS, MS , General Surgery

Oncolet contains letrozole that works in breast cancer by blocking an enzyme (aromatase) which prevents the conversion of androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) due to this levels of estrogen hormones drop in the body. The decrease in hormone levels leads to a reduction in tumor mass or delays the progression of tumor growth in some women. For an ovulation (infertility), it is presumed that Oncolet works by increasing the sensitivity of ovary to follicular stimulating hormone (FSH) and also low level of estrogen hormones in the blood is detected by the brain which in turn increases the production of a follicular stimulating hormone (FSH) which causes induction of ovulation.

Dr. Vedprakash Verma MBBS, MD , Cardiology

Yes, Oncolet and metformin can be taken together because no harmful drug interaction has been reported between them. Hence, it is safe to take Oncolet along with metformin. 

Dr. Suhas Bhargav MBBS , General Physician

Yes, Oncolet may cause breast pain. It is a rare side effect of this drug. However, the exact cause behind breast pain is not known. If you are experiencing excessive breast pain then discuss it with your doctor.

Dr. Faisal Mukhtar MBBS, PG Dip, DNB , Ophthalmology

Rarely, Oncolet causes weight fluctuation (weight gain or weight loss). However, the exact cause behind weight fluctuation is unknown but it is presumed that this occurs due to fluctuation in hormone levels in the body caused by this drug. If you experience any unusual sudden weight gain or loss after taking this drug, then consult it with your doctor without further delay.

Dr. Rahul Poddar MBBS, DNB, MBBS, DNB , General Surgery

Take Oncolet once daily or as advised by your doctor. It has been taken with or without food because the presence of food does not affect the absorption of this drug from the stomach. Precautions must be taken in patients with osteoporosis, fracture, and improper liver function.