Naloxone Benefits & Uses

Naloxone is used to treat the following -

Other Benefits

Opioid Toxicity

Naloxone Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group	Dosage
Adult	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 2 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: Dose given up to 10 mg, IV, SC dose are also same
Geriatric	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 2 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: Dose given up to 10 mg, IV, SC dose are also same
13 - 18 years (Adolescent)	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 2 mg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: Dose for 5 to 17 years old children and weighing more than 20 kg
2 - 12 years (Child)	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 0.1 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: Dose for 2 - 5 years old children only and younger than 20 kg
Infant (1 month to 2 years)	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 0.1 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor
Neonates (0 to 1 month)	Disease: Opioid Toxicity Before or After Meal: As advised by a physician Single Maximum Dose: 0.1 mg/kg Dosage Route: Parenteral Frequency: doctor administered Course Duration: As directed by the doctor Special Instructions: As prescribed by the doctor

Naloxone Side Effects

Based on research, the following side effects have been observed when Naloxone is used -

Naloxone Related Warnings

Is the use of Naloxone safe for pregnant women?

Naloxone is safe for pregnant women.

Safe
Is the use of Naloxone safe during breastfeeding?

Naloxone does not show any side effects in breastfeeding women.

Safe
What is the effect of Naloxone on the Kidneys?

Very few cases of side effects of Naloxone on kidney have been reported.

Mild
What is the effect of Naloxone on the Liver?

Naloxone is rarely harmful for the liver.

Mild
What is the effect of Naloxone on the Heart?

Naloxone is rarely harmful for the heart.

Mild

Severe Interaction of Naloxone with Other Drugs

Naloxone should not be taken with following medicines due to severe side effects it may cause to patients -

Moderate

Codeine

Pentazocine

Tramadol

Paracetamol,Codeine

Paracetamol,Tramadol

Naloxone Contraindications

If you are suffering from any of the following diseases, you should not take Naloxone unless your doctor advises you to do so -

Asthma
COPD (Chronic Obstructive Pulmonary Disease)
Gastritis
Liver Disease
Heart Disease
Kidney Disease
Blood Infection (Sepsis)

Frequently asked Questions about Naloxone

Is this Naloxone habit forming or addictive?

No, there is no any evidence that Naloxone is addictive.

No
Is it safe to drive or operate heavy machinery when consuming?

Yes, it is safe to do these activities or work after taking Naloxone as it does not make you drowsy.

Safe
Is it safe?

Yes, but take Naloxone only as per medical advice.

Safe, but take only on Doctor's advise
Is it able to treat mental disorders?

There is no benefit of taking Naloxone for mental disorders.

No

Naloxone Interactions with Food and Alcohol

Interaction between Food and Naloxone

Taking Naloxone with food does not harm your health.

Safe
Interaction between Alcohol and Naloxone

Due to lack of research, there is no information about the side effects of taking Naloxone with alcohol.

Unknown

See all substitutes for Naloxone

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

References

April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 890-892

KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 483

US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Narcan® (naloxone hydrochloride)

Naloxone Injection