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  1. myUpchar
  2. Critical illness
  3. Cancer
  4. Chronic Lymphocytic Leukemia
  5. Gazyva

Gazyva 1000mg Injection

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40ml Injection in 1 Vial Out of Stock
₹ 399305
40ml Injection 1 Vial ₹ 399305
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Gazyva 1000mg Injection

40ml Injection in 1 Vial
₹ 399305
40ml Injection | 1 Vial
₹ 399305
0 people have bought this recently
Free shipping all over India

Gazyva Information

Gazyva (Obinutuzumab) is a monoclonal antibody used to treat certain types of blood cancers. It specifically targets the CD20 protein found on B-lymphocytes, leading to the destruction of these cancer cells. It is commonly used in combination with other medications for more effective treatment.

Uses

  • Chronic Lymphocytic Leukemia (CLL): Used in combination with chlorambucil.
  • Follicular Lymphoma (FL): Used in patients who have relapsed or are refractory to prior treatment.

Mechanism of Action

Obinutuzumab is an anti-CD20 monoclonal antibody. It binds to the CD20 antigen on B-cells, triggering antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct cell death, leading to B-cell depletion.

Dosage

Chronic Lymphocytic Leukemia (CLL):

  • Cycle 1: 100 mg on Day 1, 900 mg on Day 2, and 1000 mg on Days 8 and 15.
  • Subsequent cycles (2-6): 1000 mg on Day 1 of each cycle (every 28 days).

Follicular Lymphoma (FL):

  • Induction: 1000 mg on Days 1, 8, and 15 of Cycle 1, then 1000 mg on Day 1 of subsequent cycles.
  • Maintenance: 1000 mg every 2 months for up to 2 years.

Side Effects

Common Side Effects:

  • Fatigue, nausea, diarrhea, and fever.
  • Infusion-related reactions such as chills and low blood pressure.

Serious Side Effects:

  • Tumor lysis syndrome.
  • Infections due to weakened immune response.
  • Hepatitis B virus reactivation.

Precautions

  • Premedication with antihistamines, antipyretics, and corticosteroids is required to minimize infusion-related reactions.
  • Monitor patients for signs of infection or hepatitis B reactivation.
  • Live vaccines should be avoided during treatment.

Onset and Duration of Action

  • Onset: The therapeutic effect can be seen after the first infusion.
  • Duration: B-cell depletion may persist for several months post-treatment.

Contraindications

  • Known hypersensitivity to Obinutuzumab or any component of the formulation.
  • Severe infection or active hepatitis B infection.

Storage

  • Store refrigerated at 2°C to 8°C.
  • Do not freeze or shake. Protect from light.
  1. Gazyva Benefits & Uses
  2. Gazyva Dosage & How to Take
  3. Gazyva Related Warnings
  4. Severe Interaction of Gazyva with Other Drugs
  5. Gazyva Contraindications
  6. Frequently asked Questions about Gazyva
  7. Gazyva Interactions with Food and Alcohol

Gazyva Benefits & Uses

Gazyva is used to treat the following -

Main Benefits

Other Benefits

Gazyva Dosage & How to Take

This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.

Find the right dosage based on disease and age

Age Group Dosage

Gazyva Related Warnings

  • Is the use of Gazyva safe for pregnant women?


    Gazyva shows severe side effect on pregnant women. For this reason, pregnant women should only take it after taking medical advice.

    Severe

  • Is the use of Gazyva safe during breastfeeding?


    Women who are breastfeeding may experience severe harmful effects after taking Gazyva. It should only be taken after medical advice.

    Severe

  • What is the effect of Gazyva on the Kidneys?


    Gazyva is not harmful for kidneys.

    Safe

  • What is the effect of Gazyva on the Liver?


    Gazyva can have moderate side effects on the liver. If you notice any harmful effects then stop taking this drug right away. Consult your doctor before using this medicine again.

    Moderate

  • What is the effect of Gazyva on the Heart?


    Very few cases of side effects of Gazyva on the heart have been reported.

    Mild

Severe Interaction of Gazyva with Other Drugs

Gazyva should not be taken with following medicines due to severe side effects it may cause to patients -

Severe

MethotrexateParacetamolIsoniazid

Moderate

Cyclosporin

Mild

LisinoprilAmlodipine

Gazyva Contraindications

If you are suffering from any of the following diseases, you should not take Gazyva unless your doctor advises you to do so -

Frequently asked Questions about Gazyva

  • Is this Gazyva habit forming or addictive?


    No, there is no any evidence that Gazyva is addictive.

    No

  • Is it safe to drive or operate heavy machinery when consuming?


    No, you should do not do anything that requires concentration and attention as the Gazyva can make you feel drowsy.

    Dangerous

  • Is it safe?


    Yes, Gazyva is safe but you must consult your doctor before taking it.

    Safe, but take only on Doctor's advise

  • Is it able to treat mental disorders?


    Gazyva is unable to treat or cure mental disorders.

    No

Gazyva Interactions with Food and Alcohol

  • Interaction between Food and Gazyva


    Taking Gazyva with food does not harm your health.

    Safe

  • Interaction between Alcohol and Gazyva


    Information about the interaction of Gazyva and alcohol is not currently available because this topic has not been researched yet.

    Unknown

See all substitutes for Gazyva

This medicine data has been created by -

Vikas Chauhan

B.Pharma, Pharmacy
5 Years of Experience

In stock alternatives of Gazyva (based on Obinutuzumab)

Gazyva 1000mg Injection
Gazyva 1000mg Injection 40ml Injection in 1 Vial ₹380000 3993054% off
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