Cadria, containing Doxorubicin as the active ingredient, is a chemotherapy medication used in the treatment of various types of cancers. It belongs to the anthracycline class of drugs and works by interfering with the growth and spread of cancer cells. 

Uses:

1. Breast cancer.
2. Ovarian cancer.
3. Lung cancer.
4. Lymphomas (Hodgkin’s and non-Hodgkin’s).
5. Acute leukemia.
6. Sarcomas.

Doxorubicin inhibits the replication of DNA in cancer cells by intercalating between base pairs of DNA strands. It also generates free radicals, causing damage to the cancer cells.

Dosage Forms and Strengths:
Cadria is available as an injection in vials of varying strengths, including:

• 10 mg/5 mL vial
• 50 mg/25 mL vial

Administration:

• Administered intravenously (IV) under the supervision of a healthcare professional.
• Dosage varies depending on the type of cancer, patient’s body surface area, and overall health.

Side Effects:
Common side effects

• Nausea and vomiting.
• Hair loss (alopecia).
• Fatigue.
• Low blood cell counts (anemia, neutropenia, thrombocytopenia).
• Mouth sores.
• Diarrhea.

Serious side effects:

• Heart damage (cardiotoxicity).
• Severe allergic reactions.
• Secondary cancers like leukemia (rare).

Precautions:

• Monitor heart function regularly, as Doxorubicin can cause cardiotoxicity.
• Avoid in patients with severe liver impairment.
• Use with caution in elderly patients and those with pre-existing heart conditions.
• Do not use during pregnancy or breastfeeding without medical advice.

Storage Instructions:

• Store at 2–8°C.
• Protect from light.