What is phosphorus test?

Phosphorus test is a blood test that quantifies the inorganic phosphate levels in blood. Phosphorus is a mineral found commonly in regular meals and is stored in bones and teeth. About 65% of the phosphorus consumed through meals is absorbed in the gastrointestinal tract. The exact quantity of absorbed phosphorus varies based on factors such as the status of vitamin D, source of phosphorus and the ratio of calcium to phosphorus intake. Phosphorus plays many critical functions in human body, such as:

  • Production of protein and energy through various processes
  • Proper and adequate functioning of nerves and muscles

Phosphorus test is also known as phosphorus blood test, phosphate test, inorganic phosphate test, serum phosphorus test, HPO4-2 test and PO4-3 test.

  1. Why is phosphorus test performed?
  2. How do you prepare for phosphorus test?
  3. How is phosphorus test performed?
  4. Phosphorus test results and normal range

Abnormally high or low levels of phosphate in the body indicate several health conditions. Therefore, this test is useful in the diagnosis of many different conditions. It is generally recommended in individuals with:

  • Suspected kidney disorder
  • Suspected gastrointestinal disease, as the absorption of phosphate occurs in the gastrointestinal tract
  • Fatigue and weakness
  • Bone problems, as phosphorus is involved in maintaining healthy bones

No special preparations are needed before this test but the doctor may recommend stopping some medicines that could affect test results. Also, the individual should inform the doctor about any herbal or vitamin supplements that may be taking as these may interfere with the results. For the same reason, consumption of certain food items, like cheese, fish, beer, cola, chocolates and different types of beans should be avoided before the test.

Do not skip any medicines without consulting the doctor.

A blood sample is needed for this test, which is collected as follows:

  • The site from which the sample is to be collected (usually the vein of an arm) is cleaned with an antiseptic solution.
  • An elastic band called a tourniquet is tied around the arm, which helps to locate the vein easily
  • The needle is then inserted into the vein in the arm or hand, and a blood sample is drawn and collected into a vial
  • The tourniquet is removed and a dressing is applied at the injection site

The needle may cause some discomfort and pain during blood collection. A stinging and pricking sensation may be experienced after the test for some time.

Common risks associated with blood tests include bleeding, infection, hematoma (accumulation of blood under the skin), bruising and lightheadedness.

Phosphorus test results may vary based on age, sex, the current and previous health status of the individual and method used for the test. Consult a doctor for the correct and most appropriate interpretation of test results.

Normal results:

The normal values of phosphorus in a healthy individual vary with age. Normal phosphorus levels range between 2.8 to 4.5 mg/dL in adults and 4.0 to 7.0 mg/dL in children.

However, these values differ slightly among various laboratories.

Abnormal results: 

A higher-than-normal level of phosphate is called hyperphosphatemia, which could be caused by:

  • Excessive vitamin D
  • Hypoparathyroidism, i.e., insufficient production of parathyroid hormones from parathyroid glands
  • A life-threatening condition called diabetic ketoacidosis seen in individuals with diabetes
  • Kidney failure
  • Excessive phosphate intake through diet
  • Liver disease
  • Consumption of phosphate-containing medicines like laxatives

A lower than normal level of phosphate is called hypophosphatemia, which can occur due to:

  • Alcohol intake
  • Low intake of phosphate-containing foods in diet
  • Hypercalcaemia, i.e., increased calcium levels in body
  • Lack of nutrition
  • Primary hyperparathyroidism, i.e., abnormally high production of hormones by the parathyroid glands
  • Lack of vitamin D resulting in diseases of the bones such as rickets in children and osteomalacia

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; Phosphorus
  2. Benioff Children's Hospital [internet]: University of California, San Francisco; Serum Phosphorus
  3. Chang AR, Anderson C. Dietary Phosphorus Intake and the Kidney. Annu Rev Nutr. 2017 Aug 21;37:321-346.
  4. Klemm KM, Klein MJ. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 15.
  5. Chernecky CC, Berger BJ. Phosphorus (inorganic phosphate) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:878-880.
  6. Smogorzewski MJ, Stubbs JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Skorecki K, Chertow GM, Marsden PA, Taal MW, Yu ASL, eds. Brenner and Rector's The Kidney. 10th ed. Philadelphia, PA: Elsevier; 2016:chap 19.
  7. Kliegman RM, Stanton BF, St. Geme JW, Schor NF. Electrolyte and acid-base disorders. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 55.
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