What is Cysticercosis (Taenia solium) Antibody test? 

Cysticercosis is a parasitic infection caused by the larvae (cysticerci) of pork tapeworm - Taenia solium

The cysticercosis antibody test is used to diagnose Taenia solium by detecting the presence of antibodies against the parasite in your blood. Antibodies are protective proteins produced by our immune system to fight intruding organisms. Our body produces various type of antibodies against Taenia solium; however, this test only checks for a specific type of antibody, called the IgG. This is because an IgG antibody gives the most accurate results for the diagnosis of pork tapeworm. 

Although Cysticercosis occurs worldwide, it is most common in areas where pigs roam freely and hygiene conditions are poor.

Cysticercosis occurs when a person accidentally swallows tapeworm eggs. The eggs are shed in the faeces of an infected individual and can spread through contaminated food, water or surfaces. Individuals swallow the eggs when they consume contaminated food or water or put contaminated fingers in their mouth. 

Once the eggs are ingested, they hatch in the intestine to release larvae which penetrate the intestinal wall and migrate through the blood to the muscles, heart, liver and other tissues where they form cysts. Cysts may also form in the skin and eyes. In extreme cases, Taenia solium cysts may form in the brain and cause serious neurological symptoms. The condition is then known as neurocysticercosis.

  1. Why is a Cysticercosis (Taenia solium) Antibody test performed?
  2. How do you prepare for a Cysticercosis (Taenia solium) Antibody test?
  3. How is a Cysticercosis (Taenia solium) Antibody test performed?
  4. What do Cysticercosis (Taenia solium) Antibody test results mean?

Your doctor will order this test if he/she suspects that you have symptoms of cysticercosis. 

It may take several months to years for the symptoms to appear after the initial infection. The symptoms may differ depending on the location, size, number and stage (degenerating, calcified etc.) of the cysts. Based on the location, the following symptoms may be seen:

  • Ocular cysticercosis (cysts in the eyes) may cause:

  • Cysts that form under the skin may cause small lumps with no additional symptoms
  • Cysts in the brain or the spinal cord (neurocysticercosis) may cause:
    • Seizures
    • Headaches 
    • Confusion
    • Lack of attention
    • Difficulty with balance
    • Accumulation of excess fluid around the brain

Some individuals with cysticercosis may show no or very mild symptoms.

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You don't need special preparations for this test. Make sure to inform the doctor if you use any routine medications or health supplements. Also, tell him/her if you have recently travelled somewhere since that could be linked to the occurrence of this infection.

Your doctor will require a blood sample for this test. The sample will be withdrawn from a vein in your arm using a sterile needle. This is a quick procedure which only takes a few minutes. You may feel slight pain as the needle goes in. Also, some people tend to get lightheaded after the test or notice a bruise at the needle insertion site. However, these symptoms will subside soon. 

If you feel nervous or anxious at the sight of blood, tell your doctor or nurse so that they can look after you better. Talking to someone to distract yourself during the test can be helpful. Breathing for relaxation can be helpful too.

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Normal results:

Normal results are reported as negative and indicate that no antibodies have been detected in your blood sample. However, a negative result does not ensure the absence of infection, as it may be possible that the sample was collected before you developed a detectable level of antibodies. A negative result may also occur if there are only a few cysts in your body or if the cysts are located in areas not easily accessible to the immune system. Hence, the test may be repeated if there is a high suspicion of cysticercosis. 

False-negative results may also occur in individuals with a severely compromised immune system.

Abnormal results:

Abnormal results are indicated as positive and suggest that you have cysticercosis. However, false-positive results may occur if you have infections caused by other parasitic worms, such as Echinococcus. Your doctor may perform other tests to confirm the diagnosis.

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. Garvey BT, Moyano LM, Ayvar V, et al. Neurocysticercosis among people living near pigs heavily infected with cysticercosis in rural endemic Peru. Am J Trop Med Hyg. 2018;98(2):558-564. PMID: 29210354
  2. Rodriguez S, Wilkins P, Dorny P. Immunological and molecular diagnosis of cysticercosis. Pathogens and Global Health. 2012;106:286-298. PMID: 23265553
  3. ARUP Labs [Internet]. University of Utah. Cysticercosis Antibody, IgG by ELISA
  4. Center for Disease Control and Prevention [internet], Atlanta (GA): US Department of Health and Human Services; Cysticercosis FAQs
  5. World Health Organization [Internet]. Geneva (SUI): World Health Organization; What is taeniasis and cysticercosis?
  6. National Organisation of Rare Disorders [Internet]. Danbury, CT, U.S. Cysticercosis
  7. Heart Matters [Internet]. British Heart Foundation. London (U.K.). Blood tests: What happens during a blood test and what can the results show?
  8. Shally Awasthi et al. Helminthic infections. BMJ. 2003 Aug 23; 327(7412): 431–433. PMID: 12933732
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