Zomelis Met

No, you should not take alcohol with Zomelis Met, because it can cause serious side effects which includes hypoglycemia (low blood sugar). The risk of hypoglycemia is higher when you're drinking and taking Zomelis Met than if you're just taking Zomelis Met. Some of the signs of hypoglycemia include dizziness, confusion, and drowsiness.

Zomelis Met helps in weight loss by reducing appetite and food intake. It also increases the insulin sensitivity in your body to work more effectively. This lead to decreased glucose production increases the use of glucose and decrease the fat deposition further helps in weight loss. However, Zomelis Met is not approved for weight loss, this is an off-label use.

Yes, you can take Zomelis Met with gliclazide, no harmful interactions have been reported between them. However, it is not necessary that no interaction can happen between these two. But before taking such kind of combination you must consult your doctor.

Lactic acidosis associated with Zomelis Met treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Zomelis Met induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Zomelis Met can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime.